DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and adgrg4a

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_021336868.1	Gene:	adgrg4a / 793963	ZFINID:	ZDB-GENE-121129-2	Length:	1201	Species:	Danio rerio

Alignment Length:	1066	Identity:	210/1066 - (19%)
Similarity:	350/1066 - (32%)	Gaps:	366/1066 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KAFNEQFC---YGSNIIAMDLQNFELSKVSQFLKKMNIS-----DFWLPIRRNDEL------MPY 169
            |||..:.|   ...|:|...|:  |||.....::.:..|     |:..|.:::.||      ...
Zfish    32 KAFTIRSCIWQLNENVIIPPLE--ELSVCVNLMRVLTTSEWTAFDYKGPGQQHVELGLAGNGGNL 94

  Fly   170 EVRLPGKSWRKEINRSLIHLQNNPNEHCL---KHT------INNQT---PADFKS---------- 212
            :..:.||.|....:.:    :||.:..||   .||      :||::   |.:..|
Zfish    95 KASIFGKEWTVAYDLA----KNNWHVVCLTWSSHTRLFQVIVNNRSFEFPLNETSPRYLAANGTL 155

  Fly   213 -----------QIVSVDCNAFLNAVCIFK--SELISNAGCPSGFGALVYQPAVCYGIDWNNTTYE 264
                       .||......||..:.:|:  .|.:|         ||......|  :|.|..|:
Zfish   156 SLGVSHSFVGGNIVFETGKNFLGDMSLFRIWKEQMS---------ALQLAEFRC--VDGNIVTW- 208

  Fly   265 PLDLKEYLKKRNWLRRILAKYVLKKNRHEFFKIDFFIHHSTKME---YVIKMSLS---------- 316
                    :.::|               ::.|......:|.|.|   |.|:|.||
Zfish   209 --------RTQDW---------------DYQKCPSLPDNSLKCESSKYKIQMHLSITQNTNNDNT 250

  Fly   317 EDFQIVSKGLKWI--PTLSKQIVKSSSAVEMVLEIDHRSKGVRLVIYNRKYLWKNN--NSYVGVK 377
            :..::|...||:|  |   |.:|.|.|...:.|:......|..:.....|...|..  :..|.|:
Zfish   251 DSQEMVLSWLKYIFHP---KIMVHSVSLSSISLQTGADLTGENMEAVQEKPRIKTQWFDCVVFVR 312

  Fly   378 CF----ALLKYGTLKNVRLDLIWENQEQSYS---ILKVNIVSSYRTEYWCEGHSIFEFQLVSTRL 435
            ..    ..:...|:|.:.:      ...|||   :|..|.||               ..::|..:
Zfish   313 VIPAEDVSITVSTIKTLLI------PSYSYSADIVLMTNPVS---------------INILSVAV 356

  Fly   436 FVDVNRS-----IAPVFVLRWNVSCI---NANFAYNLCDEVTDKNLRK--LIESVYGNNNLGNLL 490
            ..:|..|     |:|||....|:..|   |......|...:..:.:.|  ||.|.:..|.....:
Zfish   357 LPNVTLSPAVSTISPVFSQTTNIPGIGSTNITTVVTLMSSLRTQAMDKICLISSSFTLNKEFGDI 421

  Fly   491 IYDVRIMNI--------------EWIK-----------NMCV--------VFWIHITATLKSTAS 522
            .|.|. :||              :|::           |:.:        .|.:...|.:..||
Zfish   422 FYRVN-LNITMSGSITDPKHTLEQWLQETLQRCRMDVWNIVIKGEPKYKTTFQVQALAPVNETA- 484

  Fly   523 TYHKEIAFVDNTPRIPKDFV--AFMKVKITLSNFFLNFIKNSTYLLRSTD--YCFSELSFSNDGM 583
                       |.|:..:.:  .::...|.:|      :......:...|  .|..|...:..||
Zfish   485 -----------TERLIFELLTQGYINASIAIS------VPTGEVNITQIDPGLCPEEAMLTVYGM 532

  Fly   584 HLWWTTTRIGEIAMTKKLCIQKDGMPYTRLCLGDFVHGAYWKKLTQPVVCESPKNNTKVLH---- 644
            ::|.:.|...:..:|   |: |.....||.|.   ::||     |...:.|:| :.:|.|.
Zfish   533 YMWPSMTAQSQYELT---CV-KGNESATRFCK---LNGA-----TDKAIWEAP-DMSKCLKTVSD 584

  Fly   645 --DLQVAKMFKSPPEKVLKYLKDIIANSKNSIVPADIFLIYKIFQSVHEIH------SSN----- 696
              ||:...:.....|.::..::|:: |.:..:..|.:.::.:....|.|:.      ||:
Zfish   585 FGDLENITVTPGNSEYIVDMIEDLL-NEQTGLSNAQLDIMLEKLSEVTEVGTLTPDLSSSITNIV 648

  Fly   697 SEFQQTTKDLTNWKNAIYEIFDIY---NVLIGLDSKVIKMSAELNATNMFLKSFEMLF---DTLS 755
            ||....|.:||...|.|..|.|:.   .|..|            :|.||...|..:..   ||..
Zfish   649 SEICHITTNLTQVTNKILSITDLMGDRTVFAG------------DAHNMTAPSLALQLINPDTSQ 701

  Fly   756 LNNLSF----TQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIANVSGIALFANNN 816
            .:.|:|    .|.|...|...|.|  ..:..|.|.       :.:.|:.|:|.|     .|.|:
Zfish   702 FHGLTFEVSSVQNDGTPEIFYDEN--FTENPDTGT-------VAFISLPPTIEN-----FFPNS- 751

  Fly   817 KKNTPTKLKGAFKNEHYRFLQVNHNINDVVNEPDLELAAYLPIELIDTLQASTNKTNDVIVVIKV 881
                     ||.....:.|
Zfish   752 ---------GARPRVQFHF---------------------------------------------- 761

  Fly   882 YSNDELFQQSVRNLTLLSRVVSISLPGYS-SFLPVPVPLIFRKSKNKKVNPPGSCLVWNYE---- 941
            |..::||:.:..||||.|.|||.|:...: |.|.:||.:..|..:||:......|:.|::.
Zfish   762 YGKEKLFEDTSSNLTLNSYVVSASVTNATVSELEIPVMVTLRHLQNKEDWDIVKCVYWDFNKNDK 826

  Fly   942 --GWID-GYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDLRMSNTKLNGN---- 999
              ||.| |..:::   :|.....|....|...|..|:               :|.|.:|..
Zfish   827 KGGWNDRGCEIVN---SNATQTSCSCDHLTHFGVLLD---------------ISKTPINPKDEWV 873

  Fly  1000 ---IIYV------ILLSCCILMFIGF 1016
               |.||      |.|...:|.::.|
Zfish   874 LTIISYVGCGISSIFLGVTLLTYLAF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
adgrg4a	XP_021336868.1	LamG	50..210	CDD:328935	35/185 (19%)
		HsdR	<637..>729	CDD:333053	26/105 (25%)
		GPS	815..858	CDD:307782	10/45 (22%)
		7tmB2_GPR112	871..1138	CDD:320663	7/29 (24%)
		TM helix 1	873..898	CDD:320663	6/24 (25%)
		TM helix 2	908..930	CDD:320663
		TM helix 3	941..968	CDD:320663
		TM helix 4	983..999	CDD:320663
		TM helix 5	1028..1051	CDD:320663
		TM helix 6	1073..1098	CDD:320663
		TM helix 7	1102..1127	CDD:320663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910