DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43968 and ADGRG6

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	965	Identity:	181/965 - (18%)
Similarity:	328/965 - (33%)	Gaps:	278/965 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 PNEHCLKHTINNQTPADFKSQIVSVDCNAFLNAVCIFKSELISNAGCPSGFGALVYQPAVCYGID 257
            ||......|:  :.|..:..||...|.:......||:.|..:.|....:.|..     |...|:.
Human    63 PNSQACMWTL--RAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCG-----ATAKGLS 120

  Fly   258 WNNTTYEPLDLKEYLKKRNWLRRILAKYVLKKNRHEFFKIDFFIHH------------STKMEYV 310
            :|::..|                          .|..|..||.|..            |.:.:.|
Human   121 FNSSANE--------------------------MHVSFSSDFSIQKKGFNASYIRVAVSLRNQKV 159

  Fly   311 IKMSLSEDFQI-VSKGLKWIPTLSKQIVKSSSAVEMVLE---IDHRSKGVRLVIYNRKYLWKNNN 371
            |....|:.:|: |:|.:. ||.|        ||..:..|   :.|.........|       :|.
Human   160 ILPQTSDAYQVSVAKSIS-IPEL--------SAFTLCFEATKVGHEDSDWTAFSY-------SNA 208

  Fly   372 SYVGVKCFALLKYGTLKNV-------------------------RLDLIWENQEQSYSILKVNIV 411
            |:..:..|...|.|...::                         :|.|:|.|   |...:.||..
Human   209 SFTQLLSFGKAKSGYFLSISDSKCLLNNALPVKEKEDIFAESFEQLCLVWNN---SLGSIGVNFK 270

  Fly   412 SSYRTEYWCEGHSIFEFQLVSTRLFVDVNRS-----IAPVFVLR-WN-------VSCINANFAYN 463
            .:|.| ..|:. :|.:....:.:|.:..|::     ...::..| ||       :|.::.|...|
Human   271 RNYET-VPCDS-TISKVIPGNGKLLLGSNQNEIVSLKGDIYNFRLWNFTMNAKILSNLSCNVKGN 333

  Fly   464 LCDEVTD-KNLRKLIESVYGNNNLGNLLI--YDVRIMNIEWIKNMCVVFWIHITATLKSTASTYH 525
            :.|...| .|:..|......|.:.|:.||  ....:.:...:..:|       .||:.|.::|..
Human   334 VVDWQNDFWNIPNLALKAESNLSCGSYLIPLPAAELASCADLGTLC-------QATVNSPSTTPP 391

  Fly   526 KEIAFVDNTPRIPK---DFVAF--------------MKVKITLSNFFLNFIKNSTYLLRSTDYCF 573
            .....:..|.||.|   |.:.:              :||:..::.:..:..:|..|.:...:..|
Human   392 TVTTNMPVTNRIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISF 456

  Fly   574 SELSFSNDGMH------------LWW--------TTTRIGEIAMTKKLCIQKDGMPYTRL----- 613
             .||...|.:.            ||.        .|...|:|...|.|...:......||
Human   457 -HLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQKLLKNNESLDEGLRLHTVNV 520

  Fly   614 -----CLG-DFVHGAYWKKLTQPV----------------VCESPKNNTKVLH--DLQVAKMFKS 654
                 ||. :...|.||..: ||.                :|.....|..|.:  .:.::...|.
Human   521 RQLGHCLAMEEPKGYYWPSI-QPSEYVLPCPDKPGFSASRICFYNATNPLVTYWGPVDISNCLKE 584

  Fly   655 PPEKVLKYLKDIIANSKNSIVPADIFLIYKIFQSVHEIHSSNSEFQQTTKDLTNWKNAIYEIFDI 719
            ..| |...:.::.|:.:| :..|:   |..|.:.|..|.:.....     |:| ..:.:..||.
Human   585 ANE-VANQILNLTADGQN-LTSAN---ITNIVEQVKRIVNKEENI-----DIT-LGSTLMNIFS- 637

  Fly   720 YNVLIGLDSKVIKMSAELNATNMFLKSFEMLFDTLSLNNLSFTQIDNGEEHLNDFNSETIDYDDI 784
             |:|...||.:::.|:|.      ||:.:.|...:.||:.|         |:|      |...::
Human   638 -NILSSSDSDLLESSSEA------LKTIDELAFKIDLNSTS---------HVN------ITTRNL 680

  Fly   785 GVSVYVSKYILYFSIIPSIANVSGIALFANNNKKNTPTKLKGAFKNEHYRFLQVNHNINDVVNEP 849
            .:||        .|::|....:|..::...:|             ||.|  .|::.....|
Human   681 ALSV--------SSLLPGTNAISNFSIGLPSN-------------NESY--FQMDFESGQV---- 718

  Fly   850 DLELAAYLPIELIDTLQASTNKTNDVIVVIKV----YSNDELFQQ-SVRNLTLLSRVVSISLPGY 909
            |...:..||..|::.|     ...|.::|.:.    ::...|||. ..:..||:|.|::.|:...
Human   719 DPLASVILPPNLLENL-----SPEDSVLVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNI 778

  Fly   910 S-SFLPVPVPLIFRKSKNKKVNPPGSCLVW------NYEGWIDGYSMLSYFENNEGIALCRLRRL 967
            : ..|..||.:..:.::.::|:.| .|..|      ::.|| :....:::.:::....:|.....
Human   779 TIQNLKDPVQIKIKHTRTQEVHHP-ICAFWDLNKNKSFGGW-NTSGCVAHRDSDASETVCLCNHF 841

  Fly   968 APTGYFLEKKISIENHIINHDLRMSNTKLNGNIIYV------ILLSCCILMFIGF 1016
            ...|..::...|..      .|...|||:...|.|:      |..:..:|.::.|
Human   842 THFGVLMDLPRSAS------QLDARNTKVLTFISYIGCGISAIFSAATLLTYVAF 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001	21/116 (18%)
		LamG	154..338	CDD:304605	39/204 (19%)
		GPS	802..847	CDD:280071	7/46 (15%)
		7tm_4	864..1111	CDD:304433	5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810