DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and adgre10

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_021333746.1	Gene:	adgre10 / 569655	ZFINID:	ZDB-GENE-090313-152	Length:	690	Species:	Danio rerio

Alignment Length:	446	Identity:	96/446 - (21%)
Similarity:	168/446 - (37%)	Gaps:	142/446 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 GEIAMTKKLCIQKDGMPYTRLCLGDFVHGAYWKKLTQPVVCESPKNNTKVLHDLQVAKMFKSPPE 657
            |:..:.....||      .:.|.|::  ..|  :|..|::|.:           ..|.:..:..|
Zfish   118 GDCCLNGSFSIQ------VKACPGNY--SVY--ELISPLICSA-----------YCADVHTTLEE 161

  Fly   658 KVLKY-LKDIIANSKNSIVPADIFLIYKIFQSVHEIHSSNSEFQQTTKDLTNWKNAIYEIFDIYN 721
            ....: .||.:.|.        :.||..|...|..:::           :||:.:.:.|..:.:.
Zfish   162 ACTDWTAKDCLVNI--------LELIENITVQVLPLNT-----------VTNYLDMVLEATEKFL 207

  Fly   722 VLIGLDSKVIKMSAEL-NATNMFLKSFEMLFDTL-----SLNNLSFTQIDNGEEHLNDFNSETID 780
            |....||     .||| :..|..|:|.|.|..||     :..|:||| ::|.|.|:  |.
Zfish   208 VSSSSDS-----PAELASYGNRVLESTEKLISTLVKLTDTSANVSFT-LENVEGHV--FM----- 259

  Fly   781 YDDIGVSVYVSKYILYFSIIPSIANVSGIALFANNNKKNTPTKLKGAFKNEHYRFLQVNHNINDV 845
               :|.:|.::: ||..:...|..::..|.: |.|||......:  ||.:  |..::   |:
Zfish   260 ---VGPNVTLNE-ILQLNTTNSFMDIDLIGI-AKNNKDTRSAAV--AFMS--YTIME---NL--- 309

  Fly   846 VNEPDLELAAYLPIELIDTLQASTNKTNDVIVVIKVYSNDELFQQSVRNLTLLSRVVSISLPGYS 910
                       |..:..:| |.:|||                        |::|.|:|.:||..|
Zfish   310 -----------LKADFFNT-QKNTNK------------------------TMMSTVISATLPKTS 338

  Fly   911 -SFLPVPVPLIFRKSKNKKVNPPG--SCLVWNYEGWI-DGYSMLSYFENNEGIALCRLRRLAPTG 971
             :.|..||...||..  ::.:|.|  ||:.||...|| ||.|:|:   :|....:|....|:...
Zfish   339 NTALTKPVNFTFRHI--REFDPSGSLSCVYWNISEWIVDGCSVLN---SNSSHTVCSCVHLSTFA 398

  Fly   972 YFLEKKISIENHIINHDLRMSNTKLNGNIIYVILLSCCI-------LMFIGFLFCK 1020
            ..::               .|::....:::.::.|.|.|       |..:.|..|:
Zfish   399 LIMQ---------------TSSSPPPSDLLDLLNLVCVIVGLVFFSLALLSFALCQ 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
adgre10	XP_021333746.1	GPS	360..406	CDD:197639	15/63 (24%)
		7tm_GPCRs	413..672	CDD:333717	6/27 (22%)
		TM helix 1	413..437	CDD:320095	5/23 (22%)
		TM helix 2	446..467	CDD:320095
		TM helix 3	481..503	CDD:320095
		TM helix 4	527..543	CDD:320095
		TM helix 5	561..584	CDD:320095
		TM helix 6	608..631	CDD:320095
		TM helix 7	635..660	CDD:320095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900