DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and Adgre5

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_036055.2	Gene:	Adgre5 / 26364	MGIID:	1347095	Length:	818	Species:	Mus musculus

Alignment Length:	757	Identity:	135/757 - (17%)
Similarity:	222/757 - (29%)	Gaps:	294/757 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 GVKCFALLKYGTLKNVRLDLIWENQEQSYSILKVNIVSSYRTEYWCEGHSIFEFQLVSTRLFV-- 437
            ||:|..||    :..:.|.|.....:::         .|.....||..:|    :.||.|..|
Mouse     3 GVRCPGLL----VVCILLSLSGAGTQKA---------ESKNCAKWCPINS----KCVSNRSCVCK 50

  Fly   438 ------------------DVNRSIAPVFVLRWNVSCINANFAYN-LCDEVTDKNLRKLIESVYGN 483
                              |:|..:.|.|.......|.|:..:|. :|
Mouse    51 PGFSSEKELITNPAESCEDINECLLPGFSCGDFAMCKNSEGSYTCVC------------------ 97

  Fly   484 NNLGNLLIYDVRIMNIEWIKNMC----------VVFWIHITAT----LKSTASTYHKEIAFVDNT 534
             |||..|:...... :...:|.|          |...||...|    |....:|.| :....|:.
Mouse    98 -NLGYKLLSGAESF-VNESENTCQASVNTGMTPVPSRIHTVTTAPGNLPEQTTTVH-QTQMGDSE 159

  Fly   535 PRIPKDFVAFMKVKITLSNFFLNFIKNSTYLLRSTDYCFSELSFSNDGMHLWWTTTRIGEIAMTK 599
            .|.|||                            .:.|.|..:..:...|   ...::|..:
Mouse   160 ERTPKD----------------------------VNECISGQNHCHQSTH---CINKLGGYS--- 190

  Fly   600 KLCIQKDGM---------PYTRLC-----LGDFVH------------GAY-------WK----KL 627
              ||.:.|.         |.:.:|     .....|            |:|       ||    .|
Mouse   191 --CICRQGWKPVPGSPNGPVSTVCEDVDECSSGQHQCHNSTVCKNTVGSYKCHCRPGWKPTSGSL 253

  Fly   628 TQP-VVCESPKNNTKVLHDLQVAKMFKSPPEKVLKYLKDIIANSKNSIVPADI-FLIYKIFQSVH 690
            ..| .:|:.|...|..|  |..|.     .:.:|::..: :.|......||.: :.|.|:.::|.
Mouse   254 RGPDTICQEPPFPTWTL--LPTAH-----SQTLLRFSVE-VQNLLRDFNPATVNYTIQKLIEAVD 310

  Fly   691 EI--HSSNSEFQQTTKDLTNWKNAIYEIFDIYNVLIGLDSKVIKMSAELNATNMFLKSFEMLFDT 753
            ::  ....:|.||....|.:                       .:...|.....||......:.:
Mouse   311 KLLEDPMETETQQVAAQLLS-----------------------NLEQSLRTLAQFLPKGPFTYTS 352

  Fly   754 -----LSL-----NNLSFTQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIANVSG 808
                 |||     :|...|.:.:|:..:.      :|: .:.....:|:         :.::|:|
Mouse   353 PSNTELSLMVKEQDNKDVTTVHHGQTWME------LDW-AVTAGAKISE---------NGSSVAG 401

  Fly   809 IALFANNNK--KNTPTKLKGAFKNEHYRFLQVNHNINDVVNEPDLELAAYLPIELIDTLQASTNK 871
            |....|..|  .|||..|:           |...::.|....|       :|
Mouse   402 ILSSPNMEKLLGNTPLNLE-----------QRRASLEDFYGSP-------IP------------- 435

  Fly   872 TNDVIVVIKVYSNDELFQQSVRNLTLLSRVVSISLPGYSS-FLPVPVPLIFRKSKNKKVNPPGS- 934
                               || :|.|||.:.|:.|...:: .|...|...|..:..:.:.|...
Mouse   436 -------------------SV-SLKLLSNINSVFLTNTNTEKLASNVTFKFDFTSVESIEPRHEL 480

  Fly   935 -CLVW---NYEGW--IDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDLRMSN 993
             |..|   |..|:  .||.||       .|...|....|  |.:.:   :..:.|:  .|.|:..
Mouse   481 ICAFWKAHNGNGYWDTDGCSM-------NGTGFCHCNHL--TSFAI---LMAQYHV--QDPRLEL 531

  Fly   994 TKLNGNIIYVILLSCCILMF------------IGFLFCKCIF 1023
            ....|.::.:|.|..|||.|            :....|.|:|
Mouse   532 ITKVGLLLSLICLLLCILTFLLVKPIQSSRTMVHLHLCICLF 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
Adgre5	NP_036055.2	EGF_CA	69..118	CDD:284955	13/68 (19%)
		EGF_CA	165..212	CDD:284955	9/82 (11%)
		EGF_CA	214..248	CDD:284955	4/33 (12%)
		GPS	480..518	CDD:280071	12/49 (24%)
		7tm_2	526..766	CDD:278432	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900