DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and Adgrf5

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_038938942.1	Gene:	Adgrf5 / 245977	RGDID:	621679	Length:	1426	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	185/1080 - (17%)
Similarity:	345/1080 - (31%)	Gaps:	358/1080 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KSNHQILMRVCDT---NYGHW------------IPDLI--------ECK---IKKNKNLHCPDDL 99
            |:|.|::..:..|   :|..:            .|:.|        ||:   :..|.:....:..
  Rat   259 KANEQVIQNLNQTYKMDYNSFQGTPSNETKFTVTPEFIFEGDNVTLECESEFVSSNTSWFYGEKR 323

  Fly   100 FEIQN----------VGNIPICLKISTEPKAFNEQFCYGSNIIAMDLQNFELSKVSQFLKKMNIS 154
            .:|||          :.||.:..:::......::...||.| :.:|:  ||...|    :|::::
  Rat   324 SDIQNSDKFSIHTSIINNISLVTRLTIFNFTQHDAGLYGCN-VTLDI--FEYGTV----RKLDVT 381

  Fly   155 DFWLPIRRNDELMPYEVRLPGKSWRKEINRSLIHLQNNP-NEHCLKHTINNQTPADFKSQIVSVD 218
                           .:|:..|..||.:      ..||| :.:|....|.|.:..::|.:
  Rat   382 ---------------PIRILAKEERKVV------CDNNPISLNCCSENIANWSRIEWKQE----- 420

  Fly   219 CNAFLNAVCIFKSELISNAGCPSGFGALVYQPAVCYGIDWNNTTYEPLDLKEYLKKRNWLRRILA 283
              ..:|.......:.:.:.|...|..::             ||.....||:.          ..:
  Rat   421 --GKINIEGQTSKDEVHSTGRGRGDTSV-------------NTGTPETDLES----------SCS 460

  Fly   284 KYVLKKNRHE----------FFKIDFFIHHSTKMEYVIKMSLSEDFQIVSKGLKWIPTLSKQIVK 338
            .|.||.:..:          .:..:|...:.                  :||.|.|......:..
  Rat   461 TYTLKADGTQCPSGSSGTTVIYTCEFVSVYG------------------AKGSKNIAVTFTSVGD 507

  Fly   339 SSS-------AVEMVLEIDHRSKGVRLVIYNRKYLWKNNNSYVGVKCFALLKYGTLKNVRLDLIW 396
            :||       |...|:|:    ..|:....||....|:......:            .:..|.|.
  Rat   508 NSSYKGEVPEAPRHVMEV----STVQSTTGNRLETSKSQEQQANL------------TITPDPIS 556

  Fly   397 ENQEQSYSILKVNIVSSYRTEYWCEGHSI-FEFQLVSTRLFVDVNRSIAPV--FVLRWN--VSCI 456
            .::.||:||..::.|||:...||.....| ...:..:.|.:.|...|:..|  ....||  ..||
  Rat   557 VSEGQSFSITCLSDVSSFDEVYWNTSAGIKIHPRFYTMRRYRDGAESVLTVKTSTREWNGTYHCI 621

  Fly   457 NANFAYNLCDEVTDKNLR---KLIESVYGNNNLGNLLIYDVRIMNIEWIKNMCV----------- 507
               |.|.....:..|::.   ..:||             |:.:..:| ...:|.
  Rat   622 ---FRYKNSYSIATKDVTVHPLPLES-------------DIMMDPLE-ASGLCTSSHQFKCCIEE 669

  Fly   508 ------VFWIHI-TATLKSTASTYHKEIAFVDNTP-----RIPKDFVAFMKVKITLSNFFLNFIK 560
                  :...|: :::..:......|:..:..:.|     |.|||.           :.|.:|..
  Rat   670 NDGEEYIVTFHVDSSSFPAEREVIGKQACYTYSLPGKLPSRCPKDI-----------DVFCHFTN 723

  Fly   561 NSTYLLRSTDYCFSELSFSNDGMHLWWTTTR-----IGEIA-MTKKLCI---------QKDGMPY 610
            .:...:||.....:.:...|       .|.:     |||.. :.:|||.         |..|...
  Rat   724 AANSSVRSPSMKLTLVPGKN-------ITCQDPIIGIGEPGKVIQKLCQFAGVSRSPGQTIGGTV 781

  Fly   611 TRLCLGDFVHGAYWKKLTQPVVCESPKNNTKVLHDLQVAK-MFKSP--PEKVLKYLKDI-IANSK 671
            |..|:     |:.||:.|:..: .:|.|..     ||:|| :.|||  .:|:.|||:|: ::..|
  Rat   782 TYKCV-----GSQWKEETRACI-SAPINGL-----LQLAKALIKSPSQDQKLPKYLRDLSVSTGK 835

  Fly   672 NS----IVPADIFLIYKIFQSVHEIHSS-NSEFQQTTKDLTNWKNAIYEIFDIYNVLIGLDSKVI 731
            ..    ..|..:..|..|...:..:.:. |||..:             :|....||:  ||...:
  Rat   836 EEQDIRSSPGSLGAIISILDLLSTVPTQVNSEMMR-------------DILATINVI--LDKSTL 885

  Fly   732 K-----MSAELNATNMFLKSFEMLFDTLSLNNLSFTQIDNGEEHLNDFNSETIDYDDIGVSVYVS 791
            .     :..:.|.::.||:|.|.....|.|.:
  Rat   886 NSWEKLLQQQSNQSSQFLQSVERFSKALELGD--------------------------------- 917

  Fly   792 KYILYFSIIPSIANVSGIALFANNNKKNTPTKLKGAFKNEHYRFLQVNHNI-NDVVNEPDLELAA 855
                  |..|        .||..|.:..:....:|..:....:|:..:.:: .||.
  Rat   918 ------STPP--------FLFHPNVQMKSMVIKRGHAQMYQQKFVFTDSDLWGDVA--------- 959

  Fly   856 YLPIELIDTLQASTNKTNDVIVVIKVYSNDELFQQSVRNLTLLSRVVSISLPGYSSFLPVPVPLI 920
                  ||..|..:.:.:..||.:...:...:..|..:..|..:.:|..:...::...|..:.:.
  Rat   960 ------IDECQLGSLQPDSSIVTVAFPTLKAILAQDGQRKTPSNSLVMTTTVSHNIVKPFRISMT 1018

  Fly   921 FRKSKNKKVNPPGSCLVWNYE------GW-IDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKI 978
            |:.:......|  .|:.||:.      || ..|.::.....:|.....|:.
  Rat  1019 FKNNHRSGGKP--QCVFWNFSLANNTGGWDSSGCTVEDDGRDNRDRVFCKC-------------- 1067

  Fly   979 SIENHIINHDLRMSNTKLNGNIIYVILLSCCILMFIGFLF 1018
               ||:.:..:.||....:...:..|||.  |:.:||..|
  Rat  1068 ---NHLTSFSILMSPDSPDPGSLLKILLD--IISYIGLGF 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
Adgrf5	XP_038938942.1	FR3	592..622	CDD:409353	8/32 (25%)
		Ig strand E	602..608	CDD:409353	1/5 (20%)
		Ig strand F	616..623	CDD:409353	2/9 (22%)
		CDR3	623..632	CDD:409353	1/8 (13%)
		GPS	1029..1076	CDD:396408	11/65 (17%)
		7tm_GPCRs	1090..1363	CDD:421689	7/15 (47%)
		TM helix 1	1091..1116	CDD:410628	6/14 (43%)
		TM helix 2	1131..1153	CDD:410628
		TM helix 3	1167..1190	CDD:410628
		TM helix 4	1210..1226	CDD:410628
		TM helix 5	1248..1271	CDD:410628
		TM helix 6	1295..1320	CDD:410628
		TM helix 7	1325..1350	CDD:410628
		SEA	181..273	CDD:396113	4/13 (31%)
		IG	298..372	CDD:214652	13/76 (17%)
		Ig_3	548..621	CDD:404760	18/84 (21%)
		FR1	548..567	CDD:409353	6/30 (20%)
		Ig strand A	548..551	CDD:409353	0/14 (0%)
		Ig strand A'	555..557	CDD:409353	1/1 (100%)
		Ig strand B	561..568	CDD:409353	4/6 (67%)
		CDR1	568..575	CDD:409353	3/6 (50%)
		Ig strand D	591..598	CDD:409353	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900