DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and ADGRL2

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001352934.1	Gene:	ADGRL2 / 23266	HGNCID:	18582	Length:	1469	Species:	Homo sapiens

Alignment Length:	1059	Identity:	173/1059 - (16%)
Similarity:	336/1059 - (31%)	Gaps:	388/1059 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 CYGSNIIAMDLQNF-----ELSKVSQFLKKMNISDFWLPIRRNDELMPYEVRLPGKSWRKEINRS 185
            |.||::|.::..|:     ::.....|  :|..:|.:||                     :..:.
Human    51 CPGSDVIMIESANYGRTDDKICDADPF--QMENTDCYLP---------------------DAFKI 92

  Fly   186 LIHLQNNPNEHCLKHT----INNQTPADFKSQIVSVDC---------------NAFLNAVCIFKS 231
            :....||..: |:..|    ..:..|..:|...|..:|               .|.:::.||:::
Human    93 MTQRCNNRTQ-CIVVTGSDVFPDPCPGTYKYLEVQYECVPYMEQKVFVCPGTLKAIVDSPCIYEA 156

  Fly   232 ELISNAGCPSGFGALVYQPAVCYGIDWNNTTYEPLDLKEYLKKRNWLRRILAKYVLKKNRHEFFK 296
            |..:.|.|.                       :||...:.:....|..               ::
Human   157 EQKAGAWCK-----------------------DPLQAADKIYFMPWTP---------------YR 183

  Fly   297 IDFFIHHSTKMEYVIKMSLSEDFQIVSKGLKWIPTLSKQIVKSSSAVEMVLEIDHRSKGVRLVIY 361
            .|      |.:||.   || ||||                   :|......::.:|..|...|:|
Human   184 TD------TLIEYA---SL-EDFQ-------------------NSRQTTTYKLPNRVDGTGFVVY 219

  Fly   362 NRKYLWKNNNSYVGVKCF----------ALLKYGTLKNVR---------LDL-IWEN-------Q 399
            :....:....:...|| |          |::.|....:..         :|| :.||       .
Human   220 DGAVFFNKERTRNIVK-FDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYAT 283

  Fly   400 EQSYSILKVNIVSSYRTEYWCEGHSIFEFQLVSTRLFVDVNRSIAPVFVLRWNVSCINANFAYNL 464
            ||:..::.::.::.|...:.....::::.:..|....:     ...::|:|
Human   284 EQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMI-----CGVLYVVR-------------- 329

  Fly   465 CDEVTDKNLRKLIESVYGNNNLGNLLIYDVRIMNIEWIKNMCVVFWIHITATLKSTASTYHKEIA 529
              .|...|     ||..|.|::.  .||:.|:...|::.   |.|            ...::.||
Human   330 --SVYQDN-----ESETGKNSID--YIYNTRLNRGEYVD---VPF------------PNQYQYIA 370

  Fly   530 FVDNTPRIPKDFVAFMKVKITLSNFFLNF-----------IKNSTYLLRSTDYCFSELSFSNDGM 583
            .||..||..:.:|       ..:||.|.:           :..:...:.|:...|..:..:..
Human   371 AVDYNPRDNQLYV-------WNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTS-- 426

  Fly   584 HLWWTTTRIGEIAMTKKLCIQKDGM---------------PYT-------RLCLGDFVHGAYWKK 626
                ||::.|.::.|  :...::|.               |.|       |.|......|..|.:
Human   427 ----TTSQKGPMSTT--VAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQ 485

  Fly   627 LTQPVVCESP-----KNNTKVL------------HDL---------QVAKMFKSPPEKVLKYLKD 665
            ..:.::.|.|     :.....|            .||         |:|:..:| .|.......:
Human   486 TQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRS-GENAASLANE 549

  Fly   666 IIANSKNSIVPADIFLIYKIFQSVHEI----------------HSSNSEFQQTTKDLTNWKNAIY 714
            :..::|..:...|:....::.:.:.:|                ..|.::.|:..|....:..||.
Human   550 LAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIV 614

  Fly   715 EIFDIYNVL--IGLDS-KVIKMSAELNATNMFLKSFEMLFDTLSLNNLSFTQIDNGEEHLNDFNS 776
            :..|  |:|  ..|:| |.:..|.:.:...|.|.:.|.....|:.|.|..|::....|::
Human   615 DTVD--NLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENI----- 672

  Fly   777 ETIDYDDIGVSVYVSKYILYFSIIPSIANV-------------SGIALFANNNKKNTPTKLKGAF 828
                             :|..:::.:...:             |.|.|.||..|:|:...|
Human   673 -----------------VLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGL---- 716

  Fly   829 KNEHYRFLQVNHNINDVVNEPDLELAAYLPI-ELIDTLQASTNKTNDVIVVIKVYSNDELFQQSV 892
                                ..|....|..: :.:.|..|:.....|.|               .
Human   717 --------------------AKLVFIIYRSLGQFLSTENATIKLGADFI---------------G 746

  Fly   893 RNLTLL--SRVVSISLPGYSSFLPVPVPLIFRKSKNKKVNPP----GSCLVWNYEGWIDGYSMLS 951
            ||.|:.  |.|:|:|:...||.:.:..|::|..   ..::|.    .:|..|||    ...:|:.
Human   747 RNSTIAVNSHVISVSINKESSRVYLTDPVLFTL---PHIDPDNYFNANCSFWNY----SERTMMG 804

  Fly   952 YF--------ENNEGIALCRLRRLAPTGYFL-EKKISIENHIINHDLRMSNTKLNGNIIYVILLS 1007
            |:        :.|:....|....|......: .::|:.::.:  |:|.::.....|.:|.::.|:
Human   805 YWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGV--HELLLTVITWVGIVISLVCLA 867

  Fly  1008 CCILMFIGFLFCKCIFRRL 1026
            .||..|       |.||.|
Human   868 ICIFTF-------CFFRGL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
ADGRL2	NP_001352934.1	Gal_Lectin	49..129	CDD:307994	17/101 (17%)
		OLF	142..398	CDD:321983	61/373 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..460		5/41 (12%)
		HormR	469..533	CDD:214468	9/63 (14%)
		GAIN	542..764	CDD:318649	45/284 (16%)
		GPS	788..840	CDD:197639	9/55 (16%)
		7tmB2_Latrophilin-2	848..1105	CDD:320672	11/39 (28%)
		TM helix 1	850..875	CDD:320672	6/31 (19%)
		TM helix 2	884..906	CDD:320672
		TM helix 3	915..942	CDD:320672
		TM helix 4	954..974	CDD:320672
		TM helix 5	991..1020	CDD:320672
		TM helix 6	1036..1063	CDD:320672
		TM helix 7	1067..1092	CDD:320672
		Latrophilin	1104..1469	CDD:308136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1368..1410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810