DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and Adgrf5

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_006524187.1	Gene:	Adgrf5 / 224792	MGIID:	2182928	Length:	1406	Species:	Mus musculus

Alignment Length:	1069	Identity:	194/1069 - (18%)
Similarity:	356/1069 - (33%)	Gaps:	359/1069 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KSNHQILMRVCDT---NYGHW------------IPDLI--------ECK---IKKNKNLHCPDDL 99
            |:|.|::..:..|   :|..:            ||:.|        ||:   :..|.:.:..:..
Mouse   262 KANEQVIQNLNHTYKMDYNSFQGTPSNETKFTVIPEFIFEGDNVTLECETEFVTSNTSWYYGEKR 326

  Fly   100 FEIQN----------VGNIPICLKISTEPKAFNEQFCYGSNIIAMDLQNFELSKVSQFLKKMNIS 154
            .:|||          :.||.:..:::......::...||.| :.:|:  ||...|    :|::::
Mouse   327 SDIQNSDKYSIHTTVINNISLITRLTIYNFTQHDAGMYGCN-VTLDI--FEYGTV----RKLDVT 384

  Fly   155 DFWLPIRRNDELMPYEVRLPGKSWRKEINRSLIHLQNNP-NEHCLKHTINNQTPADFKSQ-IVSV 217
                           .:|:..|..||.:      ..|:| :.:|....|.|.:..::|.: .:|:
Mouse   385 ---------------PIRILAKEERKVV------CDNHPISLNCCSENIANWSSIEWKQEGKISI 428

  Fly   218 DCN--AFLNAVCIFKSELISNAGCPSGFG--ALVY--------------QPAVCYGIDWNNTTYE 264
            ..|  :.|.:.|...:.......||||..  .::|              ..||.:....:|.:|:
Mouse   429 LGNPESDLESSCSTYTLKADGTQCPSGSSGTTVIYTCEFVSAYGARGSKNIAVTFTSVGDNASYK 493

  Fly   265 PLDLKEYLKKRNWLRRILAKYVLKKNRHEFFKIDFFIHHSTKMEYVIKMSLSEDFQIVSKGLKWI 329
            . ::.|.      ||.::....::.....      .:..|...|....::::.|...||:|..:
Mouse   494 G-EVPEV------LRHVMEVSTVQSTTGN------SLETSKPQEQPANLTITRDPISVSEGQSF- 544

  Fly   330 PTLSKQIVKSSSAVEMVLEIDHRSKGVRLVIYNRKYLWKNNNSYVGVKCFALLKYGTLKNVRLDL 394
                     |.:.:..|...|.        :|     |   |:..|:|...  ::.|::..
Mouse   545 ---------SITCLSDVSSFDE--------VY-----W---NTSAGIKIHP--RFYTMRRY---- 578

  Fly   395 IWENQEQSYSILKVNIVSSYRTEYWCEG--HSIFEFQ---LVSTRLFVDVNRSIAPVFVLRWNVS 454
                |:.:.|:|.|..    .|..| .|  |.||.::   .::|:   ||.....|:      ||
Mouse   579 ----QDGAESVLMVKT----STREW-NGTYHCIFRYKNSYSIATK---DVTVHPLPL------VS 625

  Fly   455 CINAN--FAYNLCDEVTDKNLRKLIESVYGNNNLGNLLIYDVRIMNIEWIKNMCVVFWIHITATL 517
            .|..:  .|..||  .:....:..:|...|                    :...|.|  |:.::.
Mouse   626 DIMMDPLEASGLC--TSSHQFKCCVEEDAG--------------------EEYAVTF--HVDSSS 666

  Fly   518 ---------KSTASTYHKEIAFVDNTPRIPKDFVAFMKVKITLSNFFLNFIKNSTYLLRSTDYCF 573
                     |....||    :...|.||.|||...|.        .|.|...:|   :||.....
Mouse   667 FPAEREVIGKQACYTY----SLPANLPRCPKDIAVFC--------HFTNAANSS---VRSPSMKL 716

  Fly   574 SELSFSNDGMHLWWTTTR-----IGEIA-MTKKLCI---------QKDGMPYTRLCLGDFVHGAY 623
            ..:...|       .|.:     ||:.. :.:|||.         |..|...|..|:     |..
Mouse   717 KLIPREN-------VTCQDPIIGIGDPGKVIQKLCQFSGVYGSPGQAIGGTVTYKCV-----GTQ 769

  Fly   624 WKKLTQPVVCESPKNNTKVLHDLQVAK-MFKSP--PEKVLKYLKDIIANS-------KNSIVPAD 678
            ||:.::..: .:|.|..     ||||| :.|||  .:|:..||:|:..::       ::|  |..
Mouse   770 WKEESRACI-SAPINGL-----LQVAKALIKSPTQDQKLPTYLRDLSVSAGKEEQDIRSS--PGS 826

  Fly   679 IFLIYKIFQSVHEIHSS-NSEFQQTTKDLTNWKNAIYEIFDIYNVLI---GLDSKVIKMSAELNA 739
            :..|..|...:..:.:. |||..:             :|....||::   .|:|....:..:.|.
Mouse   827 LGAIISILDLLSTVPTQVNSEMMR-------------DILATINVILDKSALNSWEKLLQQQSNQ 878

  Fly   740 TNMFLKSFEMLFDTLSLNNLSFTQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIA 804
            ::.||.|.|.....|.|.:                                       |..|.:|
Mouse   879 SSQFLHSVERFSQALQLGD---------------------------------------STPPFLA 904

  Fly   805 NVSGIALFANNNKKNTPTKLKG-AFKNEHYRFLQVNHNINDVVNEPDL--ELAAYLPIELIDTLQ 866
            :.:              .::|. ..|..|.:..|...    :..:.||  ::|       ||..|
Mouse   905 HPN--------------VQMKSMVIKRGHPQIYQQQF----IFKDSDLWGDVA-------IDECQ 944

  Fly   867 ASTNKTNDVIVVIKVYSNDELFQQSVRNLTLLSRVVSISLPGYSSFLPVPVPLIFRKSKNKKVNP 931
            ....:.:..||.:...:...:..|.|:..|..:.:|..:...::...|..:.:.|:.:......|
Mouse   945 LGNLQPDSSIVTVAFPTLKAILAQDVQRKTSSNSLVMTTTVSHNIVKPFRISMTFKNNHRSGGKP 1009

  Fly   932 PGSCLVWNYE------GW-IDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDL 989
              .|:.||:.      || ..|.|:.....:|.....|:.                 ||:.:..:
Mouse  1010 --QCVFWNFSLANNTGGWDSSGCSVEDDGRDNRDRVFCKC-----------------NHLTSFSI 1055

  Fly   990 RMSNTKLNGNIIYVILLSCCILMFIGFLF 1018
            .||....:...:..|||.  |:.:||..|
Mouse  1056 LMSPDSPDPGSLLKILLD--IISYIGLGF 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
Adgrf5	XP_006524187.1	IG	301..375	CDD:214652	13/76 (17%)
		ig	535..608	CDD:365836	22/113 (19%)
		GPS	1009..1056	CDD:366827	12/65 (18%)
		7tm_GPCRs	1070..1343	CDD:391938	7/15 (47%)
		TM helix 1	1071..1096	CDD:341315	6/14 (43%)
		TM helix 2	1111..1133	CDD:341315
		TM helix 3	1147..1170	CDD:341315
		TM helix 4	1190..1206	CDD:341315
		TM helix 5	1228..1251	CDD:341315
		TM helix 6	1275..1300	CDD:341315
		TM helix 7	1305..1330	CDD:341315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900