Protein Alignment CG43968 and ADGRF5

DIOPT Version :10

• Sequence 1: NP_001262238.1
• Gene: CG43968 / 14462915
• FlyBaseID: FBgn0264699
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: XP_005248949.1
• Gene: ADGRF5 / 221395
• HGNCID: 19030
• Length: 1386
• Species: Homo sapiens
• Alignment Length: 1178
• Identity: 218/1178 - (18%)
• Similarity: 384/1178 - (32%)
• Gaps: 432/1178 - (36%)

  Fly    52 AISEDLLCLKSNHQILMRVCDTNYGHWIPDLIECKIKKNKNLHCPD-DLFEIQNVGNIPICLKIS 115
            :|:...:|..:.::|... |:|.|| |..:  .|.    .||.|.: |:|   ..|:...||| .
Human   104 SINVTTVCRPAGNEIWCS-CETGYG-WPRE--RCL----HNLICQERDVF---LPGHHCSCLK-E 156

  Fly   116 TEPKAFNEQFCYGSNIIAMDLQ-------NFELSKVSQFLKKMNISDFWLPIRRNDELMP----- 168
            ..|   |..||.....:.::::       ..:|...|..|.:...:|.....|:...::|
Human   157 LPP---NGPFCLLQEDVTLNMRVRLNVGFQEDLMNTSSALYRSYKTDLETAFRKGYGILPGFKGV 218

  Fly   169 -------------YEVRLPGKSWRKEINRSLIHLQNNPNEHCLKHTINNQTPADFKS-QIVSV-D 218
                         |||:....|      ..|||   ..||..:: ::|.....|:.| |.|:: :
Human   219 TVTGFKSGSVVVTYEVKTTPPS------LELIH---KANEQVVQ-SLNQTYKMDYNSFQAVTINE 273

  Fly   219 CNAFLNAVCIFKSELISNAGCPSGFGALVYQPAV-CYGIDW----------------------NN 260
            .|.|:....||:.:.:|          ||.:..| ...:.|                      ||
Human   274 SNFFVTPEIIFEGDTVS----------LVCEKEVLSSNVSWRYEEQQLEIQNSSRFSIYTALFNN 328

  Fly   261 TT---------YEPLDLKEYLKKRNWLRRILAKYVLKKNRHEFFKIDFFIHHSTKMEYVIKMSLS 316
            .|         ..|.|..||:.|   |...:.:|..||      |||..         .|::..:
Human   329 MTSVSKLTIHNITPGDAGEYVCK---LILDIFEYECKK------KIDVM---------PIQILAN 375

  Fly   317 EDFQIV-----------SKG-LKWIPTLSKQIVK-----------SSSAVEMVLEID-----HRS 353
            |:.:::           |:| :.|.....||..|           .||.....|:.|     ..|
Human   376 EEMKVMCDNNPVSLNCCSQGNVNWSKVEWKQEGKINIPGTPETDIDSSCSRYTLKADGTQCPSGS 440

  Fly   354 KGVRLVIYNRKYLWKNNNSYVGVKCFALLK-----------------------------YGTLKN 389
            .|. .|||..:::     |..|.:..|.:|                             ..|.:|
Human   441 SGT-TVIYTCEFI-----SAYGARGSANIKVTFISVGDNSSHKSEVHEVLRHVMEMSTVQSTTRN 499

  Fly   390 ---------------VRLDLIWENQEQSYSILKVNIVSSYRTEYW--CEGHSIFEFQLVSTRLFV 437
                           :..|.|..::.|::||..::.||:|...||  ..|..|:: :..:||.::
Human   500 SLETSKAQEQQANLTITPDPISVSEGQNFSIKCISDVSNYDEVYWNTSAGIKIYQ-RFYTTRRYL 563

  Fly   438 DVNRSIAPV--FVLRWN--VSCINANFAYNLCDEVTDKNLRKLIESVYGNNNLGNLLIYDVRIMN 498
            |...|:..|  ....||  ..||   |.|                     .|..::...||.:..
Human   564 DGAESVLTVKTSTREWNGTYHCI---FRY---------------------KNSYSIATKDVIVHP 604

  Fly   499 IEWIKNMCVVFWIHITATLKSTASTYHK---------EIAFVDNTPRIPKDFVAFMKVKITLSNF 554
            :....|:.|   ..:.||:..:.|.:.|         ::.|...:..:|    |..:|......:
Human   605 LPLKLNIMV---DPLEATVSCSGSHHIKCCIEEDGDYKVTFHTGSSSLP----AAKEVNKKQVCY 662

  Fly   555 FLNFIKNS-TYLLRSTDYCFSELSFSNDGMHLWWTTTR------------------IGEIA-MTK 599
            ..||..:| ::..::.|.|   ..|:|...:..|:.:.                  :||.. :.:
Human   663 KHNFNASSVSWCSKTVDVC---CHFTNAANNSVWSPSMKLNLVPGENITCQDPVIGVGEPGKVIQ 724

  Fly   600 KLCIQKD---------GMPYTRLCLGDFVHGAYWKKLTQPVVCESPKNNTKVLHDLQVAK-MFKS 654
            |||...:         |...|..|:     |:.|::.....: .:|.|:.     ||:|| :.||
Human   725 KLCRFSNVPSSPESPIGGTITYKCV-----GSQWEEKRNDCI-SAPINSL-----LQMAKALIKS 778

  Fly   655 P--PEKVLKYLKDIIANSKNSIVPADIFLIYKIFQSVHEIHSSNSEFQQTTKDLTNWKNAIYEIF 717
            |  .|.:..||||               |...|.::.|||.||....           .||..|.
Human   779 PSQDEMLPTYLKD---------------LSISIDKAEHEISSSPGSL-----------GAIINIL 817

  Fly   718 DI-------------------YNVLIG---LDSKVIKMSAELNATNMFLKSFEMLFDTLSLNN-- 758
            |:                   .||::|   |::..:......|.::..|.|.|.....|...:
Human   818 DLLSTVPTQVNSEMMTHVLSTVNVILGKPVLNTWKVLQQQWTNQSSQLLHSVERFSQALQSGDSP 882

  Fly   759 -LSFTQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIANVSGIALFANNNKKNTPT 822
             |||:|                      .:|.:|..::                     |.:.|.
Human   883 PLSFSQ----------------------TNVQMSSMVI---------------------KSSHPE 904

  Fly   823 KLKGAFKNEHYRFLQVNHNINDVVNEPDLELAAYLPIELIDTLQASTNKTNDVIVVIKVYSNDEL 887
            ..:..|.   :.:..:..|:  |:::..||           .||:.::     ||.:...:...:
Human   905 TYQQRFV---FPYFDLWGNV--VIDKSYLE-----------NLQSDSS-----IVTMAFPTLQAI 948

  Fly   888 FQQSVRNLTLLSRVVSISLPGYSSFLPVPVPLIFRKSKNKKVNPPG---SCLVWNYE------GW 943
            ..|.::.......:|..:...:::.:|..:.:.|:.:     :|.|   .|:.||:.      ||
Human   949 LAQDIQENNFAESLVMTTTVSHNTTMPFRISMTFKNN-----SPSGGETKCVFWNFRLANNTGGW 1008

  Fly   944 IDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDLRMSNTKLNGNIIYVILLSC 1008
               .|...|.|..:|                :....|.:|:.:..:.||....:.:.:..|||..
Human  1009 ---DSSGCYVEEGDG----------------DNVTCICDHLTSFSILMSPDSPDPSSLLGILLDI 1054

  Fly  1009 CILMFIGF 1016
            ...:.:||
Human  1055 ISYVGVGF 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
ADGRF5	XP_005248949.1	SEA	179..281	CDD:470595	22/111 (20%)
		IG_like	285..361	CDD:214653	15/88 (17%)
		Ig strand B	289..293	CDD:409353	2/13 (15%)
		Ig strand C	301..305	CDD:409353	0/3 (0%)
		Ig strand E	333..337	CDD:409353	0/3 (0%)
		Ig strand F	347..351	CDD:409353	2/3 (67%)
		IG_like	517..602	CDD:214653	26/109 (24%)
		GPS	993..1036	CDD:460350	11/61 (18%)
		7tmB2_GPR116_Ig-Hepta	1049..1323	CDD:320382	5/14 (36%)
		TM helix 1	1051..1076	CDD:320382	4/12 (33%)
		TM helix 2	1091..1113	CDD:320382
		TM helix 3	1127..1150	CDD:320382
		TM helix 4	1170..1186	CDD:320382
		TM helix 5	1208..1231	CDD:320382
		TM helix 6	1255..1280	CDD:320382
		TM helix 7	1285..1310	CDD:320382