DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	989	Identity:	185/989 - (18%)
Similarity:	328/989 - (33%)	Gaps:	342/989 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 PNEHCLKHTINNQTPADFKSQIVSVDCNAFLNAVCIFKSELISNAGCPSGFGALVYQPAVCYGID 257
            ||......|:  :.||.:..||...|.:......||:.|..:.|....:.|..     |...|:.
Mouse    72 PNTQSCSWTL--RAPAGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCG-----ATAKGLS 129

  Fly   258 WNNTTYEPLDLKEYLKKRNWLRRILAKYVLKKNRHEFFKIDFFIHH------------STKMEYV 310
            :|::..|                          .|..|..||.|..            |.:.:.|
Mouse   130 FNSSVNE--------------------------MHVSFSSDFSIQKKGFNASYIRVAVSLRNQKV 168

  Fly   311 IKMSLSEDFQI-VSKGLKWIP-----TLSKQIVK-------------SSSAVEMVLEIDHRSKGV 356
            |.....:.:|: |:|.:. ||     ||..:..|             |..::..:|.::..|.|.
Mouse   169 ILPQTLDAYQVSVAKSIS-IPELKAFTLCFEASKVGNEGGDWTAFSYSDESLTQLLSLEKASNGY 232

  Fly   357 RLVIYNRKYLWKNNNSYVGVKCFALLKYGTLKNVRLDLIWENQEQ-------SYSILKVNIVSSY 414
            .|             |..|.:|  ||........:.|:..||.||       |:..:.:|...:|
Mouse   233 FL-------------SISGSRC--LLNNALPVKDKEDIFTENLEQLCLVWNNSWGSIGINFKKNY 282

  Fly   415 RTEYWCEG-------------------------HSIFEFQL----VSTRLFVDVNRSIAPVFVLR 450
            .| ..|:.                         .||:.|:|    :..:...:::.|::. .|:.
Mouse   283 ET-VPCDSTISAVVPGDGTLLLGSDRDEVASLRGSIYNFRLWNFTMDLKALSNLSCSVSG-NVID 345

  Fly   451 W----------------NVSC------------INANFAYNLCDEVTD----------KNLRKLI 477
            |                |:||            .|.:....||.....          .|: .:.
Mouse   346 WHNDFWSISTQALKAEGNLSCGSYLIQLPAAELTNCSELGTLCQATVSPPSTPPPTVTTNI-PVT 409

  Fly   478 ESVYGNNNLGNLLIYDVRIMN-------------IEWIKNMCVVFWIHITATLKSTASTYHKEIA 529
            ..|:...|.|.:....|.|.|             .||: |.....|.:   |:.....::|:::.
Mouse   410 NRVHKQKNDGIMYRISVVIHNDFNHPEVKVQTKVAEWL-NSTFQNWNY---TVYVVNISFHQKVG 470

  Fly   530 FVDNTPRIPKDFV---------AFMKVKITLSNFFLN-------FIKNSTYL---LRSTDYCFSE 575
              ::..::.:|.:         |.:....| :|..||       .:.|:..|   ||..:...::
Mouse   471 --EDRMKVKRDIMDDDKRLVLWALLVYNAT-NNVSLNEEKIKQKLMTNNASLEDGLRLCEVDVNQ 532

  Fly   576 LSFSN-----DGMHLWWTTTRIGEIAMTKKLCIQKDGMPYTRLCLGDFVHGAYWKKLTQPV---V 632
            |...:     ||..  |..|.   .::.|:.|..|.|...||.||.:.. ..:|    .||   .
Mouse   533 LGMCSALEDPDGFS--WPATL---PSVYKQPCPNKPGFFMTRACLSNGT-STFW----GPVDTSN 587

  Fly   633 CESPKNNTKVLHDLQVAKMFKSPPEKVLKYLKD---IIANSKNSIVPADIFLIYKIFQSVHEIHS 694
            |....|        :||       .::|....|   :.:.:.||||.       |:.:.|:
Mouse   588 CSRQSN--------EVA-------NEILNQTGDGQNLTSANINSIVE-------KVKRIVN---- 626

  Fly   695 SNSEFQQTTKDLTNWKNAIYEIFDIYNVLIGLDSKVIKMSAELNATNMFLKSFEMLFDTLSLNNL 759
                 ::...|:| ..:.:..||.  |:|...||.:::.|.|.      ||:.:.|...:.||:.
Mouse   627 -----KEENIDIT-LGSTLMNIFS--NILSSSDSDLLESSTEA------LKTIDELAFKIDLNST 677

  Fly   760 SFTQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIANVSGIALFANNNKKNTPTKL 824
            ....|:.  ::|           .:|||          |:||.....|..::...:|
Mouse   678 PHVNIET--QNL-----------ALGVS----------SLIPGTNAPSNFSIGLPSN-------- 711

  Fly   825 KGAFKNEHYRFLQVNHNINDVVNEPDLELAAYLPIELIDTLQASTNKTNDVIVVIKV----YSND 885
                 ||.|..:...:...|.:      .:..||..|::.|     ...|.::|.:.    ::..
Mouse   712 -----NESYFQMDFGNGQTDPL------ASVILPPNLLENL-----SPEDSVLVRRAQFTFFNKT 760

  Fly   886 ELFQQ--SVRNLTLLSRVVSISLPGYS-SFLPVPVPLIFRKSKNKKVNPPGSCLVW------NYE 941
            .|||.  |.|.: |:|.|::.|:...: ..|..||.:..:.::.::|:.| .|..|      ::.
Mouse   761 GLFQDVGSQRKV-LVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHP-ICAFWDMNKNKSFG 823

  Fly   942 GW-IDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDLRMSNTKLNGNIIYVIL 1005
            || ..|....|..:..|.|.||        .:|....:.:       ||..|.::::|.
Mouse   824 GWNTSGCVAHSDLDAGETICLC--------SHFTHFGVLM-------DLPRSASQIDGR------ 867

  Fly  1006 LSCCILMFIGFLFC 1019
             :..:|.||.::.|
Mouse   868 -NTKVLTFITYIGC 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001	22/116 (19%)
		LamG	188..347	CDD:389952	30/175 (17%)
		HRM	543..588	CDD:382965	15/54 (28%)
		GPS	809..854	CDD:366827	12/53 (23%)
		7tm_GPCRs	869..1137	CDD:391938	4/12 (33%)
		TM helix 1	871..896	CDD:341315	4/10 (40%)
		TM helix 2	906..928	CDD:341315
		TM helix 3	939..966	CDD:341315
		TM helix 4	981..997	CDD:341315
		TM helix 5	1026..1049	CDD:341315
		TM helix 6	1072..1097	CDD:341315
		TM helix 7	1101..1126	CDD:341315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810