DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	691	Identity:	130/691 - (18%)
Similarity:	245/691 - (35%)	Gaps:	219/691 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 VSSYRTEYWCEGHSIFEFQLVSTRLFVDVNRSIAPVFVLRWNVSCINANFAY------------N 463
            :||:....|          |.||..|:....|.:|. ..:..||..|...::            :
Human  2212 ISSFFETTW----------LDSTPSFLSTEASTSPT-ATKSTVSFYNVEMSFSVFVEEPRIPITS 2265

  Fly   464 LCDEVTDKNLRKLIESVYGNN--NLGNL-------------LIYDVRIM---------NIEWIKN 504
            :.:|.|:.:|    .|::.|:  :|..|             ::.|..|:         .|.::..
Human  2266 VINEFTENSL----NSIFQNSEFSLATLETQIKSRDISEEEMVMDRAILEQREGQEMATISYVPY 2326

  Fly   505 MCVVFWIHITATLKSTASTYHKEIAFVDNTPRIPKDFVAFMKVKITLSNFFL--NFIKNSTYLLR 567
            .||     ....:|:::|....|:               ..|:|..:...|.  ||.::...||.
Human  2327 SCV-----CQVIIKASSSLASSEL---------------MRKIKSKIHGNFTHGNFTQDQLTLLV 2371

  Fly   568 STDY----------CFSELSFSNDGMHLWWTTTRIGEIAMTKKLCIQKDGMPYTRLCLGDFVHG- 621
            :.::          |.::.:.|.......|..|...|.|.|:  ||:.:....||.|......|
Human  2372 NCEHVAVKKLEPGNCKADETASKYKGTYKWLLTNPTETAQTR--CIKNEDGNATRFCSISINTGK 2434

  Fly   622 AYWKKLTQPVVCESPK-NNTKVLHDLQVAKMFKSPPEKVLKYLKDIIANSKNSIVPADIFLIYKI 685
            :.|:|         || ...|:|.:|         |:|::. |.:|..:.:|:...|:..|
Human  2435 SQWEK---------PKFKQCKLLQEL---------PDKIVD-LANITISDENAEDVAEHIL---- 2476

  Fly   686 FQSVHEIHSSNSEFQQTTKDLTNWKNAIYEIFDIYNVLIGLDSKVIKMSAELNATNMFLKSFEML 750
                :.|:.|.:..::.||.:      :.:|.||        |:..::|  :|.|::.|:
Human  2477 ----NLINESPALGKEETKII------VSKISDI--------SQCDEIS--MNLTHVMLQ----- 2516

  Fly   751 FDTLSLNNLSFTQIDNGEEHLNDFNSETIDYDDIGVSVYVSKYILYFSIIPSIAN--VSGIALFA 813
                 :.|:...:.:|....|::.::|.:..      :..:.:.:.||  ..|||  |:|:||
Human  2517 -----IINVVLEKQNNSASDLHEISNEILRI------IERTGHKMEFS--GQIANLTVAGLAL-- 2566

  Fly   814 NNNKKNTPTKLKG-------AFKNEHYRFLQVNHNINDVVNEPDLEL----------AAYLPIEL 861
                    ..|:|       ||....|          :...:|::.|          :.|||..|
Human  2567 --------AVLRGDHTFDGMAFSIHSY----------EEGTDPEIFLGNVPVGGILASIYLPKSL 2613

  Fly   862 IDTLQASTNKTNDVIVVIKVYSNDELFQQSVRNLT--LLSRVVSISLPG--YSSFLPVPVPLIFR 922
            .:.:..|..:|    ::...:....||:  .:|:|  |.:.|||.|:..  :...|..||.:..:
Human  2614 TERIPLSNLQT----ILFNFFGQTSLFK--TKNVTKALTTYVVSASISDDMFIQNLADPVVITLQ 2672

  Fly   923 KSKNKKVNPPGSCLVWNYE------GWIDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIE 981
            .....:......|..|::|      ||  ..|.....|.|....:|:...|...|..::...|..
Human  2673 HIGGNQNYGQVHCAFWDFENNNGLGGW--NSSGCKVKETNVNYTICQCDHLTHFGVLMDLSRSTV 2735

  Fly   982 NHIINHDLRMSNTKLNGNIIYV------ILLSCCILMFIGF 1016
            :.:        |.::...|.|.      |.|...::.:|.|
Human  2736 DSV--------NEQILALITYTGCGISSIFLGVAVVTYIAF 2768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071	11/44 (25%)
		7tm_2	2743..2982	CDD:278432	6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810