DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and mthl11

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_731479.3	Gene:	mthl11 / 117467	FlyBaseID:	FBgn0045443	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	81/356 - (22%)
Similarity:	127/356 - (35%)	Gaps:	113/356 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 FDTLSLNNLSFTQIDNGEEHLND----------FNSETIDYDDIGVSVYVSKYILYFSIIPSIAN 805
            |||:.|....  ::.||.....|          ::.| ||||  |..|.|.|:|.     ..:..
  Fly    29 FDTVQLRESE--KLCNGSYRYEDVVIPAKLTGKYDYE-IDYD--GDRVSVPKHIR-----GCVCK 83

  Fly   806 VSGIALFANNNKKNTPTKL--KGAFKNEHYRF----LQVN------HNINDVVNEPDLELAAYLP 858
            :.....|..::||.....|  :..::|..|.:    .|:|      |.:||:|.:.||.    ||
  Fly    84 LKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLP----LP 144

  Fly   859 IELIDTLQASTNKTNDVIVVIKVYSNDELFQ-------------------QSVRNLTLL------ 898
            .|...:|.|.|: |.|   :..:|.|..||:                   .:.:|.:|:
  Fly   145 CERHYSLDAETS-TYD---MWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCI 205

  Fly   899 -----------------SRVVSISLP-GYSS--FLPVPVPLI-----FRKSKNKKVNPPGSCLVW 938
                             ||:.:.|:| .:||  |:.:.:...     ||....|..|....||..
  Fly   206 QKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNLYFICLAI 270

  Fly   939 NYEGWIDGYSMLSYFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDL--RMSNTK------ 995
            .:  .::..|:...||....|  |.|...|  |||......:...:|:.|:  |.:..|
  Fly   271 TF--LLNVISLFGIFELKTPI--CYLTGYA--GYFTVMATFLWLSVISFDVWRRFAMRKFQVFYK 329

  Fly   996 ------LNGNIIY---VILLSCCILMFIGFL 1017
                  .|.|||.   ..||:|.|.:...|:
  Fly   330 NKRSSFFNYNIIVWSSAGLLTCIIFLVDQFV 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:310923	45/192 (23%)
		7tmB3_Methuselah-like	236..504	CDD:320167	31/131 (24%)
		TM helix 2	258..280	CDD:320167	5/23 (22%)
		TM helix 3	291..318	CDD:320167	7/28 (25%)
		TM helix 4	335..355	CDD:320167	8/19 (42%)
		TM helix 5	383..412	CDD:320167
		TM helix 6	433..460	CDD:320167
		TM helix 7	468..493	CDD:320167
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900