DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and adgre14

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_021330419.1	Gene:	adgre14 / 108182849	ZFINID:	ZDB-GENE-131120-49	Length:	505	Species:	Danio rerio

Alignment Length:	262	Identity:	62/262 - (23%)
Similarity:	107/262 - (40%)	Gaps:	60/262 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 DIGVSVYVSKYILYFSIIPSIANVSGIALFAN----NNK-------KNTPTKLKGAF---KNEHY 833
            |..|::::|.         |.||.:.:..:.|    ||:       |.|.|....:|   ..|..
Zfish     4 DAAVNIHMSS---------SSANPNELTSYGNRVLINNEELMSTLVKQTDTSANVSFTLADVEGR 59

  Fly   834 RFLQVNHNINDVVNEPDLELA-AYLPIELIDTLQASTNKTNDVIVVIKVYSN-DELFQQSVRNL- 895
            .|:...|...|.:  |.|... ..:.|:||. :..:.|.|....|:...|:. :.|.:....|.
Zfish    60 VFMVGPHVTLDEI--PRLHTRNCSIDIDLIG-IANNNNGTRSAAVIFLGYNTMENLLKADFFNAT 121

  Fly   896 -----TLLSRVVSISLP-GYSSFLPVPVPLIFRKSKNKKVNPPG--SCLVWNYEGWI-DGYSMLS 951
                 |::|.|:|::|| ..::.|..||...||..  ::.:|.|  ||:.||...|| ||.|:|:
Zfish   122 NDTVNTMMSSVISVTLPKTTNTALSKPVNFTFRHI--REFDPSGSFSCVYWNISKWIVDGCSVLN 184

  Fly   952 YFENNEGIALCRLRRLAPTGYFLEKKISIENHIINHDLRMSNTKLNGNIIYVILLSCCILMFIGF 1016
               .|....:|....|:.....::.:    :|....|..:       |::.|:    |::  :|.
Zfish   185 ---TNRSFTVCSCVHLSTFALIMQTR----SHPPESDSLL-------NVLNVV----CVI--VGL 229

  Fly  1017 LF 1018
            ||
Zfish   230 LF 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
adgre14	XP_021330419.1	GPS	167..205	CDD:197639	12/40 (30%)
		7tm_GPCRs	214..476	CDD:333717	7/31 (23%)
		TM helix 1	217..241	CDD:320095	6/28 (21%)
		TM helix 2	250..271	CDD:320095
		TM helix 3	285..307	CDD:320095
		TM helix 4	331..347	CDD:320095
		TM helix 5	365..388	CDD:320095
		TM helix 6	412..435	CDD:320095
		TM helix 7	439..464	CDD:320095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900