DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43968 and adgrf3a

DIOPT Version :9

Sequence 1:	NP_001262238.1	Gene:	CG43968 / 14462915	FlyBaseID:	FBgn0264699	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_021322955.1	Gene:	adgrf3a / 101886922	ZFINID:	ZDB-GENE-131121-607	Length:	949	Species:	Danio rerio

Alignment Length:	760	Identity:	138/760 - (18%)
Similarity:	256/760 - (33%)	Gaps:	203/760 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 LPGKSWRKEIN-RSLIHLQNNPNEHCLKHTINNQTPADFKSQIVSVDCNAFLNAVCIFKSE---L 233
            :||..|..::: .:...|..|....||.   :|:...|..:...|:||:...:...:..:|   |
Zfish    19 MPGYKWSDDMDCTNECELNINTTAVCLS---SNKVSIDGTTTDTSMDCSLLCDQSKVNSAEHKKL 80

  Fly   234 ISN--------------------AGCPSGFGALVYQPAVCYGIDWNNTTYEPLDLKEYLKKRNWL 278
            :.|                    .|  .|:|:||....|.|        ..|:.:.:
Zfish    81 LQNRTTMLVEKYSTLDYFNSLVITG--YGWGSLVLNYTVIY--------LGPVSIDD-------- 127

  Fly   279 RRILAKYVLKKNRHEFFK---IDFFIHHSTKMEYVIKMSL--SEDFQIVSKGLKWIPTLSK-QIV 337
               |.|.||:.:..:...   ||..|::|..::.....::  :....|.|..:||..|.|: :..
Zfish   128 ---LQKVVLQVDNTKLVTKGLIDIKINNSQPVDIYSSATIICTPPPNIGSVTVKWYLTNSQNKTT 189

  Fly   338 KSSSAVEMVLEIDHRSKGVRLVIYNRKYLWKNNNSYVGVKC-FALLKYGTLKNVRLDLIWENQEQ 401
            :.:..:|..| ..:::|...:.:.|....||..     .|| :|:.......:.:||:......|
Zfish   190 EITDGIEATL-TTNQNKISTVQLNNFSESWKGT-----FKCVYAIYGISHTASEQLDVALLPNIQ 248

  Fly   402 SYSILKVNIVSSYRTEYWCEGHSIFEFQLVSTRLFVDVNRSI-APVFVLRWN--VSCINANFAYN 463
            :.|..:..|.:|                |.||...|..|.|. :..:.:.||  .|....:.|.|
Zfish   249 ALSNPQFPICTS----------------LSSTSFKVYCNISADSENYTVTWNHSTSSTTVDTAGN 297

  Fly   464 ----------LCDEVTDKNLRKLIESVYGNNNLGNLLIYDVRIM--------------------- 497
                      |||.....|:.....:....|||.......:.|:
Zfish   298 RISYIAYVTILCDSKETLNVACTFINTRSKNNLNRTQNVQIPIIYAYSTVCDPEGGWPIAKSGYT 362

  Fly   498 --------NIEWIKNMC-VVFWIHITAT--------LKSTASTYHKEIAFV-DNTPRIPKDFVAF 544
                    .:.|....| ...|....:|        :|:.....:|.|.|: ||..::      |
Zfish   363 ATMPCDNSGVGWRTRKCNGTRWSTEISTCVNANLFDIKTDVQELNKGIGFIKDNADQL------F 421

  Fly   545 MKV--KITLSNFFLNFIKNSTYLLRSTDYCFSELSFSNDGMHLWWTTTRIGE-IAMTKKLCIQKD 606
            .::  ..||..|....|:.|..:       |..::..:......|..|.:.: ::....|.....
Zfish   422 QRINDSTTLRTFTFPNIETSVNI-------FGVMNDVSTRQQNQWNDTVMSKLVSSASNLLNDPS 479

  Fly   607 GM--PYTRLCLGDFVHGAYWKKLTQPVVCESPKNNTKVL-------HDLQVAKMFKSPPEKVLKY 662
            |.  |..:   ..|:...|.|.:      |...||:.::       .:.|:|....:.|..:.|.
Zfish   480 GWQNPENK---SIFISVEYLKTI------ERMMNNSNLISNTPYISSNAQMALCNHTSPADICKT 535

  Fly   663 LKDIIANSKNSIVPADIFLIYKIFQSVHEIHSSNSEFQQTTKDLTNWKNAIYEIFDIYNVLIGLD 727
            ....:.||.||:|......:|:|........|:.:....|..:..|...:|...||
Zfish   536 FNASVRNSDNSVVVFGFRNLYQILPKAEGNDSNTTILSVTPVNANNTNRSITLEFD--------- 591

  Fly   728 SKVIKMSAELNATN--MFLKSFEMLFDTLSLNNLSFTQIDNGE----EHLNDF------NSETID 780
                  ||:....|  ::...::...:..|.:...:..:||..    :|.:.|      |:||:.
Zfish   592 ------SAKQRLPNHMIYCVYWDENLNEWSSDGCRWAGVDNPTLCICDHNSAFTILMSKNAETLP 650

  Fly   781 YDD------IGVSV------YVSKYILYFSIIPS-IANVSGIALF 812
            |.|      :|:|:      .:.|.:::.:::.| |:|...:|||
Zfish   651 YMDELTYAGLGISILSLLACLIIKVLVWDAVVKSPISNFRHVALF 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43968	NP_001262238.1	None
adgrf3a	XP_021322955.1	GPS	604..641	CDD:307782	5/36 (14%)
		7tm_GPCRs	649..926	CDD:333717	11/47 (23%)
		TM helix 1	652..676	CDD:320095	4/23 (17%)
		TM helix 2	691..712	CDD:320095	3/5 (60%)
		TM helix 3	723..745	CDD:320095
		TM helix 4	766..782	CDD:320095
		TM helix 5	805..831	CDD:320095
		TM helix 6	855..881	CDD:320095
		TM helix 7	890..915	CDD:320095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900