DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43783 and CPEB4

DIOPT Version :9

Sequence 1:	NP_001261606.1	Gene:	CG43783 / 14462845	FlyBaseID:	FBgn0264305	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_085130.2	Gene:	CPEB4 / 80315	HGNCID:	21747	Length:	729	Species:	Homo sapiens

Alignment Length:	414	Identity:	73/414 - (17%)
Similarity:	131/414 - (31%)	Gaps:	121/414 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSATSSASGSNSNLSGSTSASASAATSPTSSGTAVGGILSGAPKSPPGLGSSTPISVRFNANEES 74
            |:..|.|:..|:|.:.:.|::.||...|..:...:...:.|:.|:              .:.::.
Human    36 NATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKA--------------KSQQQE 86

  Fly    75 LDDILQSFHHSKHSPSGGASGGGDASPTSNLLGMKNNGLGLVVGNCDSLSSSPSQPQMHAGSASL 139
            ..|.|:.   .:.|||.|...|                   ::...:...|..:|    ..::|.
Human    87 QQDPLEK---QQLSPSPGQEAG-------------------ILPETEKAKSEENQ----GDNSSE 125

  Fly   140 FGNDEVSLRNNFMQAGGFFNRKRSGSIEGVSPTSSGPSIISTLSTASAAGGGGSSV--------- 195
            .||.:..:|.......||..::.:|......|.:|..|.::..|..|||....||.
Human   126 NGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFF 190

  Fly   196 --GGAVAAGDSNSS--------------GGTWRLIKGKVTQ----------TIEEIKSSKLPPTA 234
              ||..||..:|.:              ||::....|.::|          ...:.:..:..|.:
Human   191 HQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPAS 255

  Fly   235 AIPIIVADPPSTGWSNDPDSDTECLTVNTSISEELPLDLEHKQNSDSDVEAELLQHDSISLGSGD 299
            ..|     ||              .|...:...:||    |..|:.:...:....:.|.|
Human   256 PHP-----PP--------------FTHRNAAFNQLP----HLANNLNKPPSPWSSYQSPS----- 292

  Fly   300 VPTVAAT---------------GHSERSRLRRGLAHIRSKVKAKQQAAP--AMNKKDVSPSGSTV 347
             ||.:::               |...|..|..|:..:.|....|:..|.  ...:|...||.:..
Human   293 -PTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFA 356

  Fly   348 PATSVRTGFLRRRNVVEAGSEPST 371
            |.:.:.....|..|:......|.|
Human   357 PKSWMEDSLNRADNIFPFPDRPRT 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43783	NP_001261606.1	None
CPEB4	NP_085130.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..49		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		13/94 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..328		21/138 (15%)
		RRM1_CPEB2_like	472..563	CDD:410123
		RNA-binding. /evidence=ECO:0007744\|PDB:5DIF	541..543
		RRM2_CPEB2_like	580..660	CDD:410125
		CEBP_ZZ	655..716	CDD:406704
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900