DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43783 and Tex2

DIOPT Version :9

Sequence 1:	NP_001261606.1	Gene:	CG43783 / 14462845	FlyBaseID:	FBgn0264305	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_938034.2	Gene:	Tex2 / 21763	MGIID:	102465	Length:	1128	Species:	Mus musculus

Alignment Length:	1276	Identity:	323/1276 - (25%)
Similarity:	516/1276 - (40%)	Gaps:	302/1276 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SSTPISVRFNAN---------------EESLDD-------------ILQSFHHSKHSPSGGAS-- 94
            |...|::.|:|:               ||.|||             .|:|  ...|.|:|..|
Mouse    30 SRDTIAIHFSASGEEEEEEEEEFRGYLEEGLDDQSIVTGLEAKEDLYLES--QGGHDPAGPVSTA 92

  Fly    95 --GGGDASPTSNLLGMKNNGLGLVVGNCDSLS-SSPSQPQMHAGSASLFGNDEVSLRNNFMQAGG 156
              .|...|.:..:|.:..|.:.|:.....:|. .||....:..||:|
Mouse    93 PADGLSVSESPAILPVSENTVKLLESPAPALQVLSPVPLALSPGSSS------------------ 139

  Fly   157 FFNRKRSGSIEGVSPTSSGPSIIS-----TLSTASAAGGGGSSVGGAVAAGDSNSSGGTW-RLIK 215
                  ||      |.:|.||:.|     |.|::..:....|.|..:.|:..:.||...: .|:|
Mouse   140 ------SG------PLASSPSVSSLSEQKTSSSSPLSSPSKSPVLSSSASSSALSSAKPFMSLVK 192

  Fly   216 GKVTQTIEEIKSSKLPPT-AAIPIIVADPPSTGWSNDPDSDTECLTVNTSISEELPLDLEHKQNS 279
            ...|:.  |.|.|..||. ..:...:....||..|............::.::..|.......:|:
Mouse   193 SLSTEV--EPKESPHPPRHRHLMKTLVKSLSTDTSRQESDTVSYKPPDSKLNLHLFKQFTQPRNT 255

  Fly   280 DSD---VEAELLQHDSISLGSGDVPTVAATGHSERSRLRRGL---AHIRSKVKAKQQAAPAMNKK 338
            ..|   ..:..|...|.:.....||.:.|.....:.||...:   ..:.||:..::..  :...|
Mouse   256 GGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESG--SHRPK 318

  Fly   339 DVSPSGSTVPATSVRTGFLRRRN--VVEA---------GSEPSTSQQAEI---AIASGKVKKRGI 389
            .:|.|.|.:.:.|...|.|...|  :.|.         ||:.:||:...:   ..||.:|:.:|.
Mouse   319 ALSASASELSSLSGLNGHLESNNYSIKEEEGDSEGEGYGSDSNTSRSDHLKPTEDASKEVEPKGS 383

  Fly   390 LLAR-KDVEIESGVEVLEDMIPSTAVHIDHSK--DVANKRAEEVTDAGADADSRASLTLPVAPGF 451
            ..:. ||:.:::...|||....|..|..:..:  ::..:..|..|:.....|.  :|.||:.|
Mouse   384 QASSLKDLGLKTSSLVLEKCSLSALVSKEDEEFCELYTEDFELETEGEGRLDK--TLDLPLKP-- 444

  Fly   452 STLASSYVEKESGVRDTRSRISFFSNLSMLSVSQWREKHQGATAFALPVLLSVLLIL----LMIL 512
            ..|||..|..||...:..:                 .:||     .|||......|:    .:||
Mouse   445 EVLASDGVALESEDEEDSA-----------------TEHQ-----ELPVKTLGFFIMCVYAYLIL 487

  Fly   513 PVPDFLRGVF-----------ATLLFFTVMDCCGGH--LRALLEDFMLTTHPERVAFAIPNYKFM 564
            |:|.::.|:|           ..:.|||.......|  |:||       .|....:..|
Mouse   488 PLPYYMSGLFLGVGLGFMTAVCMIWFFTPPSAHKHHKSLKAL-------RHQSTRSLDI------ 539

  Fly   565 PICEIPAVEEHKTIKTYAGWMNEINSYDPNTFSFSLTRAVYVRLDGSILKMSGTNARIPKRRMWN 629
                    :|.:.:|   ||||||.:|||.|:..:||.:|:|||:|..|::|..|..|.:|..:|
Mouse   540 --------KEPEILK---GWMNEIYNYDPETYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYN 593

  Fly   630 EPPIDRHKIPFTDHRSYDLRDCRIELLPLGLANKRFFNRKYPIQLIIKSNRDVPDEQSSVESQSE 694
            |   .:.::.:...:.|||.|.:|.|:|..||.||.:|:||||  .|:..|. .|..|..:|..|
Mouse   594 E---TKPEVTYISQKIYDLSDSKIYLVPKSLARKRIWNKKYPI--CIELGRQ-DDFMSKAQSDKE 652

  Fly   695 ATVKTDAKEAKAASSSGTTPPGGEEEKLVDFAGTVMQADLQQLRNTVNPDKELNDITVPCGDEVR 759
            ||.:....|.:..|.....||..:|       ||     ....|:.:
Mouse   653 ATEEKPPPEKELPSEDLKKPPQPQE-------GT-----KSSQRDPI------------------ 687

  Fly   760 LLLFSRCDREKEDWYRRFTNASRGLVHEQDLQVPMARFVEDSDLQAAAARQALLLVTGMGKAGVK 824
            |.||.|..||||:|:|||..|||   .:.:|:.|.......|.|..|.:|.:       ..:|..
Mouse   688 LYLFGRTGREKEEWFRRFILASR---LKSELRKPAGVSGSKSGLLPAHSRHS-------SPSGHL 742

  Fly   825 SEDEISAGKGNDETDQQTPDGQFETITEEDLLDTPKEESFDGMIMSANVARNSPDYVRFMAVYQK 889
            |... |:.||                :.|:::..||::...|.:....:.    ||    :||..
Mouse   743 SHSR-SSSKG----------------SVEEMMSQPKQKELVGSVRQKMLL----DY----SVYMG 782

  Fly   890 AC----NQSTIPVTRSSVGTMRTTDRRPRKSRRAKRQEDELWKGIDQSLFLGPSGSIVWANVLLG 950
            .|    |:|.   .||.|.:..::....:|...|...|:|     :|.         .|.|.|||
Mouse   783 RCVPQDNRSP---HRSPVQSAESSPTASKKLPEAPPSEEE-----EQE---------AWVNALLG 830

  Fly   951 RCLYSWLHDAMLHEKLKEVLQKKLNSIKLPSFMEEVIITNIYLGESPLLCHRVSQPMLDERGVWI 1015
            |..:.:|.:....:.:.:.:|.||:.||||.||.|:.:|.:.:|.:.....:..:|.:|.:|:||
Mouse   831 RIFWDFLGEKYWSDVVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWI 895

  Fly  1016 DADVTYEGLAHITVTTKLNLLRIRSKTKSPMATDNVPTTSMLPEQSQDLRSLSEVNSEN------ 1074
            |.:::|.|...:|:.||:||.::   .|.|:.               :...:.|:..|.
Mouse   896 DLEMSYNGSFLMTLETKMNLTKL---GKEPLV---------------EALKVGEIGKEGCRPRAY 942

  Fly  1075 VIYDSDAESSGGSSTESESPPPGNAPENAAGTEFFQNSPG--------NARRIFKIVDRIAASNL 1131
            .:.|||.|||...|:|.:.|     ||..||.:  |..||        ...:|.:.||:|..|..
Mouse   943 CLADSDEESSSAGSSEEDDP-----PEPTAGDK--QPLPGAEGYVGGHRTSKIMRFVDKITKSKY 1000

  Fly  1132 FQYATELPYVQRAMENM-NANITLRVDLKGLVARGTL--NVPPPPSDRVWVSFRGPPRLWISTKP 1193
            ||.|||..::::.:|.: |..:.|.|:::  ..||||  |:||||:||:|..||.||.:.:..:|
Mouse  1001 FQKATETEFIKKKIEEVSNTPLLLTVEVQ--ECRGTLAVNIPPPPTDRIWYGFRKPPYVELKARP 1063

  Fly  1194 QVGDKSVDWSIVTNVIESKLCEAVNKFLVYPNMVDFSIPFL 1234
            ::|::.|....||..||.||.:.:.|..|.|||.|..||.:
Mouse  1064 KLGEREVTLVHVTEWIEKKLEQELQKVFVMPNMDDVYIPIM 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
CG43783	NP_001261606.1	None
Tex2	NP_938034.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..99	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..279	33/180 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..387	9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..688	13/72 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..765	13/72 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..821	9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	945..981	16/42 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830672
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2238
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004193
OrthoInspector	1	1.000	-	-		oto95266
orthoMCL	1	0.900	-	-		OOG6_106829
Panther	1	1.100	-	-	O	PTHR13466
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700