DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk1 and RAS2

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	NP_014301.1	Gene:	RAS2 / 855625	SGDID:	S000005042	Length:	322	Species:	Saccharomyces cerevisiae

Alignment Length:	172	Identity:	49/172 - (28%)
Similarity:	90/172 - (52%)	Gaps:	18/172 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 YRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDDESGEKAVSVLLSGEESELIFID----HGYT 1181
            |:::::||..||||:|..|...|.::..||.:|:|...::   |::..|.|.|..:|    ..|:
Yeast    11 YKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQ---VVIDDEVSILDILDTAGQEEYS 72

  Fly  1182 EMTPDECLTNYDPHGYCVIYSAADRSS----FSVAEQVLQVLWTNQNIAQKAVILVSNKADLARS 1242
            .|. ::.:.|.:  |:.::||...:||    .:..:|:|:|..|:    ...:::|.||:||...
Yeast    73 AMR-EQYMRNGE--GFLLVYSITSKSSLDELMTYYQQILRVKDTD----YVPIVVVGNKSDLENE 130

  Fly  1243 RLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIR 1284
            :.|:.::|..||...:..|:|||.....||:|....|...:|
Yeast   131 KQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVR 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	49/172 (28%)
		small_GTPase	1121..1286	CDD:197466	49/172 (28%)
RAS2	NP_014301.1	small_GTPase	9..172	CDD:197466	48/170 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910