DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk1 and RAS1

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	NP_014744.1	Gene:	RAS1 / 854268	SGDID:	S000005627	Length:	309	Species:	Saccharomyces cerevisiae

Alignment Length:	255	Identity:	68/255 - (26%)
Similarity:	109/255 - (42%)	Gaps:	52/255 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1121 YRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDDESGEKA-----VSVL----LSGEESELIFI 1176
            |:::::||..||||:|..||:.|.::..||.:|:|...::.     ||:|    .:|:|.
Yeast    11 YKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEE----- 70

  Fly  1177 DHGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQK---AVILVSNKAD 1238
               |:.|......|.   .|:.::||...|:||   :::|......|.:...   .|::|.||.|
Yeast    71 ---YSAMREQYMRTG---EGFLLVYSVTSRNSF---DELLSYYQQIQRVKDSDYIPVVVVGNKLD 126

  Fly  1239 LARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIR----------LKLENPEKS 1293
            |...|.|:.|:|..:|...:..|:|||.....||||....|:..:|          .:|:|..:.
Yeast   127 LENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEI 191

  Fly  1294 RDLFRKRSI---RKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSSPRKYRGSRT 1350
            ||.....|.   |:.|......|:....||.|             ||:..|...:.|..|
Yeast   192 RDSELTSSATADREKKNNGSYVLDNSLTNAGT-------------GSSSKSAVNHNGETT 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	68/255 (27%)
		small_GTPase	1121..1286	CDD:197466	52/186 (28%)
RAS1	NP_014744.1	small_GTPase	9..172	CDD:197466	51/174 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910