DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk1 and Rem2

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	NP_073176.2	Gene:	Rem2 / 64626	RGDID:	69081	Length:	341	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	97/352 - (27%)
Similarity:	149/352 - (42%)	Gaps:	102/352 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1058 GVVNRGDSL------KSRRSRSNNSV-----ASSNSSTEHLTTQQQLSAPASVSARTSLASSRES 1111
            ||..|..|:      :.||:::.:.:     |||:.|::.|.           |...:||..
  Rat    62 GVPRRRGSMPVPYKHQLRRAQAVDELDWPPQASSSGSSDSLG-----------SGEAALAQK--- 112

  Fly  1112 STSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSIDDESGEKAVSVLLSGEESELIFI 1176
                  :|.::|::||...||||:|...|...:..:|::....:::.|:  .:::..||..||..
  Rat   113 ------DGVFKVMLLGESGVGKSTLAGTFGGLQGDNAHEMENSEDTYER--RIMVDKEEVTLIVY 169

  Fly  1177 D-------HGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWTNQNIAQKAVILVS 1234
            |       .|:.:   |.||...|  .:.:::|..||.|||...:.|..|...:......||||.
  Rat   170 DIWEQGDAGGWLQ---DHCLQTGD--AFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVG 229

  Fly  1235 NKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKL-------ENPEK 1292
            ||:||||||.|:.|||:.:|....||.||||..::||..||..|.:.||||:.       :.||.
  Rat   230 NKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRGHAGGQRPEP 294

  Fly  1293 SRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSSPRKYRGSRTSTSLKVK 1357
            |                            :|.||      .||           ..|.|.:.|.|
  Rat   295 S----------------------------SPDGP------APP-----------TRRESLTKKAK 314

  Fly  1358 GLLGRVWTRDSK-----SKSCENLHVL 1379
            ..|..:..|::|     |:||.:|.||
  Rat   315 RFLANLVPRNAKFFKQRSRSCHDLSVL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	80/276 (29%)
		small_GTPase	1121..1286	CDD:197466	60/171 (35%)
Rem2	NP_073176.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..106		6/32 (19%)
		RGK	116..341	CDD:206715	80/276 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..309		9/71 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8910
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020