DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rgk1 and RRAD

DIOPT Version :9

Sequence 1:NP_725875.3 Gene:Rgk1 / 14462605 FlyBaseID:FBgn0264753 Length:1379 Species:Drosophila melanogaster
Sequence 2:NP_001122322.1 Gene:RRAD / 6236 HGNCID:10446 Length:308 Species:Homo sapiens


Alignment Length:362 Identity:105/362 - (29%)
Similarity:147/362 - (40%) Gaps:98/362 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1055 TGKGVVNRGDSLKSRRSRS----------NNSVASSNSSTEHLTTQQQLSAPASVSA----RTSL 1105
            :|.|....|...:.||..|          ..|:.......:...|...|:|.|:.:.    |...
Human     8 SGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAAAGTGTQGPRLDW 72

  Fly  1106 ASSRESSTSNPGN----GPYRVLMLGGPAVGKSSLVSQFMTSE-------YLHAYDTSIDDESGE 1159
            ....|.|.|:.|:    ..|:||:||.|.||||:|...|...|       ..|.||.||      
Human    73 PEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSI------ 131

  Fly  1160 KAVSVLLSGEESELIFID---HGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSVAEQVLQVLWT 1221
                 ::.|||:.|:..|   .......|..|:...|  .|.::||..|:.||..|.::...|..
Human   132 -----VVDGEEASLMVYDIWEQDGGRWLPGHCMAMGD--AYVIVYSVTDKGSFEKASELRVQLRR 189

  Fly  1222 NQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLK 1286
            .:......:|||.||:||.|||.|:.:||:|.|..:||||||||..::|||..|..|::.||||:
Human   190 ARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLR 254

  Fly  1287 LENPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSSPRKYRGSRTS 1351
                   ||                                         |.:::.|:..|:|..
Human   255 -------RD-----------------------------------------SKEANARRQAGTRRR 271

  Fly  1352 TSL--KVKGLLGRVWTRDS-------KSKSCENLHVL 1379
            .||  |.|..|||:..|:|       |||||.:|.||
Human   272 ESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL 308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rgk1NP_725875.3 DUF2967 459..715 CDD:288079
P-loop_NTPase 1121..1379 CDD:304359 87/276 (32%)
small_GTPase 1121..1286 CDD:197466 65/174 (37%)
RRADNP_001122322.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..88 16/79 (20%)
RGK 92..308 CDD:206715 87/276 (32%)
RAS 92..252 CDD:214541 63/172 (37%)
Calmodulin-binding 278..297 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2445
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D301527at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_109169
Panther 1 1.100 - - O PTHR45775
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5084
SonicParanoid 1 1.000 - - X743
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.900

Return to query results.
Submit another query.