DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk1 and Rgk3

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	NP_001286670.1	Gene:	Rgk3 / 5740446	FlyBaseID:	FBgn0085426	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	161/447 - (36%)
Similarity:	223/447 - (49%)	Gaps:	72/447 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   965 QQQQQQQHKRDENMRQLLDVTNTLTIEELRDF---QMRYG---SPHHSRSQSVKMPGSRASGRPN 1023
            ||||||||                |::|.|.:   :.|..   :|...|..|.:.|.:.|..:.|
  Fly    80 QQQQQQQH----------------TLQETRSYCTSEPRLSETETPPQRRKLSQRRPQTHAHRKSN 128

  Fly  1024 Q-LCLPQQRSRVASMPNTGV---EEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSVASSNSST 1084
            . |.:|     ..:|.:..|   :|:..|||.||.:..|::|||||.:.||||||:...||...|
  Fly   129 AFLDVP-----TMNMHHLRVNDDDEDVDRLRTFSASKGGIINRGDSFRRRRSRSNSLAPSSPMHT 188

  Fly  1085 EHLTTQQQLSAPASVSARTSLASSRESSTSNPGNGP------------YRVLMLGGPAVGKSSLV 1137
            .:  ....|...|...:...|.......:|:.|.|.            |||.|||...|||.:|:
  Fly   189 RN--GVGGLGGVAGGGSSLGLGCGYNGGSSSNGFGNANAQENHQPVEFYRVEMLGSAGVGKQALL 251

  Fly  1138 SQFMTSEYLHAYDTSIDDESGEKAVSVLLSGEESELIFIDHGYTEMTPDECLTNYDPHGYCVIYS 1202
            |||.||:.::|||....|:: |:.||::|:|.||||.|:. |..| :.|| |...|  .:.|:||
  Fly   252 SQFRTSDCINAYDGPECDDA-EQNVSIILNGTESELKFLT-GNPE-SKDE-LEQAD--AFLVVYS 310

  Fly  1203 AADRSSFSVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVG 1267
            ..|:.||:.|:|:|..|.....:..:..|||:||.||||||.|::::||.:|..:..||||.|||
  Fly   311 CIDKESFTRAKQILSRLQDMDLLRHRPTILVANKIDLARSRAVSAQDGKCVACTFGAKFIEVSVG 375

  Fly  1268 INHNVDELLVGLLSQIRLKLE------NPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGP 1326
            ||||.||||.|.|:|||||.:      ||:||:|        |.|.:.....|...:..:..|..
  Fly   376 INHNCDELLAGTLTQIRLKKDQVQLQLNPKKSKD--------KDKNKFKENTNIETVETDNCLTD 432

  Fly  1327 LGEAVATPPGSAQSSPRKYRG-SRTSTSLKVKGLLGRVW---TRDSKSKSCENLHVL 1379
            | :|....|..|.|....|:. |....|:|.:.:|  .|   ..|||.|.||||.||
  Fly   433 L-KADDGGPRDANSPAHWYKSRSVMLASMKARQML--TWILGKEDSKFKHCENLQVL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	110/267 (41%)
		small_GTPase	1121..1286	CDD:197466	80/164 (49%)
Rgk3	NP_001286670.1	P-loop_NTPase	235..>396	CDD:422963	82/166 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I4492
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8675
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020