DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rgk1 and REM2

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	XP_016876547.1	Gene:	REM2 / 161253	HGNCID:	20248	Length:	373	Species:	Homo sapiens

Alignment Length:	563	Identity:	129/563 - (22%)
Similarity:	205/563 - (36%)	Gaps:	211/563 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 SPTDSARRRSFKNKQRHQKEEHFYIQTEDRSGTAAGNGPINVTANPLEAAAVCKQPRATIVVQQP 900
            :|..::...|.:.:.||.:   |.:          |||.....|.||             :::||
Human     3 TPVQASGDFSVRGQARHSQ---FLL----------GNGHQVGVAGPL-------------ILEQP 41

  Fly   901 SLSLDNTVETLLIKNEGDFISVEQGKELVARKRNSQQLAHPPAHLHHHTQNHAHNHHTLQQQQHQ 965
            .|||.:.||.:               .|:|    |..|   |:|.
Human    42 GLSLLHMVEHI---------------PLIA----SFSL---PSHF-------------------- 64

  Fly   966 QQQQQQHKRDENMRQLLDVTNTLTIEELRDFQMRYGSPHHSRSQSVKMPGSRASGRPNQLCLPQQ 1030
                           :|:...||.                .:|:.:.....| ||.|:....|::
Human    65 ---------------ILEADATLL----------------KKSEKLLAELDR-SGLPSAPGAPRR 97

  Fly  1031 RSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKSRRSRSNNSV-----ASSNSSTEHLTTQ 1090
            |   .|||        ...:|               :.||:::.:.:     |||:.|::.|.:.
Human    98 R---GSMP--------VPYKH---------------QLRRAQAVDELDWPPQASSSGSSDSLGSG 136

  Fly  1091 QQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQF--MTSEYLHAYDTSI 1153
            :  :|||.                  .:|.::|:::|...||||:|...|  :..:..|..:...
Human   137 E--AAPAQ------------------KDGIFKVMLVGESGVGKSTLAGTFGGLQGDSAHEPENPA 181

  Fly  1154 DDESGEKAVSVLLSGEESELIFID-------HGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSV 1211
            :|....:   :::..||..|:..|       .|:..   |.||...|  .:.:::|..||.|||.
Human   182 EDTYERR---IMVDKEEVTLVVYDIWEQGDAGGWLR---DHCLQTGD--AFLIVFSVTDRRSFSK 238

  Fly  1212 AEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELL 1276
            ..:.|..|...:......||||.||:||||||.|:.|||:.:|....||.||||..::||..||.
Human   239 VPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELF 303

  Fly  1277 VGLLSQIRLKLENPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATPPGSAQSS 1341
            .|.:.||||:           |.|:....:|.          :..:|.||      .||
Human   304 EGAVRQIRLR-----------RGRNHAGGQRP----------DPGSPEGP------APP------ 335

  Fly  1342 PRKYRGSRTSTSLKVKGLLGRVWTRDSK-----SKSCENLHVL 1379
                 ..|.|.:.|.|..|..:..|::|     |:||.:|.||
Human   336 -----ARRESLTKKAKRFLANLVPRNAKFFKQRSRSCHDLSVL 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	78/271 (29%)
		small_GTPase	1121..1286	CDD:197466	58/173 (34%)
REM2	XP_016876547.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020