DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rgk1 and Rem2

DIOPT Version :9

Sequence 1:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster
Sequence 2:	NP_542764.2	Gene:	Rem2 / 140743	MGIID:	2155260	Length:	341	Species:	Mus musculus

Alignment Length:	310	Identity:	90/310 - (29%)
Similarity:	134/310 - (43%)	Gaps:	76/310 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1092 QLSAPASVS---ARTSLASSRESSTSNPGNGPYRVLMLGGPAVGKSSLVSQFMTSEYLHAYDTSI 1153
            :|..|...|   :..||.|...:.|..  :|.::|:::|...||||:|...|...:..||::...
Mouse    86 ELDWPPQASPSGSSDSLGSGEAALTQK--DGVFKVMLVGESGVGKSTLAGTFGGLQGDHAHEMEN 148

  Fly  1154 DDESGEKAVSVLLSGEESELIFID-------HGYTEMTPDECLTNYDPHGYCVIYSAADRSSFSV 1211
            .:::.|:  .:::..||..||..|       .|:.:   |.||...|  .:.:::|..||.|||.
Mouse   149 SEDTYER--RIMVDKEEVTLIVYDIWEQGDAGGWLQ---DHCLQTGD--AFLIVFSVTDRRSFSK 206

  Fly  1212 AEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTSEEGKAMATAYDCKFIETSVGINHNVDELL 1276
            ..:.|..|...:......||||.||:||||||.|:.|||:.:|....||.||||..::||..||.
Mouse   207 VPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELF 271

  Fly  1277 VGLLSQIRLKL-------ENPEKSRDLFRKRSIRKSKRRACSPLNAGCLNANTPLGPLGEAVATP 1334
            .|.:.||||:.       :.||.|                            :|.||      .|
Mouse   272 EGAVRQIRLRRGRGHAGGQRPEPS----------------------------SPDGP------AP 302

  Fly  1335 PGSAQSSPRKYRGSRTSTSLKVKGLLGRVWTRDSK-----SKSCENLHVL 1379
            |           ..|.|.:.|.|..|..:..|::|     |:||.:|.||
Mouse   303 P-----------TRRESLTKKAKRFLANLVPRNAKFFKQRSRSCHDLSVL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	80/276 (29%)
		small_GTPase	1121..1286	CDD:197466	60/171 (35%)
Rem2	NP_542764.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..106		6/19 (32%)
		RGK	116..341	CDD:206715	80/276 (29%)
		RAS	116..279	CDD:214541	58/169 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..309		9/71 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8675
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020