DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpb4 and TADA2A

DIOPT Version :9

Sequence 1:	NP_001014633.2	Gene:	Rpb4 / 14462484	FlyBaseID:	FBgn0263757	Length:	139	Species:	Drosophila melanogaster
Sequence 2:	NP_001159577.2	Gene:	TADA2A / 6871	HGNCID:	11531	Length:	443	Species:	Homo sapiens

Alignment Length:	158	Identity:	29/158 - (18%)
Similarity:	60/158 - (37%)	Gaps:	40/158 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MNPVDMVDEDA----------ADLQFPKEFENAETLLISEVHMLLDHRKRQNESADEEQEFSEVF 58
            :..:|.|::|:          .|:...:..|......|...|.|::.||.|.......:|..:::
Human   187 LRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLY 251

  Fly    59 MKTYAYTDSFRKFK------NKETIMSARSLLMQ-----KKLHKFELAALGNLCPEAPEEAKALI 112
                   ::.|:|.      ..:..:.:.:|..:     |:|.::..|.:.|.|      :....
Human   252 -------ETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFC------SARTY 303

  Fly   113 PSLEGRFEDEEL-RQILDDIGTKRSLQY 139
            ..|:...|:|.| |.:|.::     |||
Human   304 DHLKKTREEERLKRTMLSEV-----LQY 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpb4	NP_001014633.2	RPOL4c	22..139	CDD:128904	23/128 (18%)
TADA2A	NP_001159577.2	COG5114	28..440	CDD:227445	29/158 (18%)
TADA2A	NP_001159577.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2493
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950