DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gata3 and pnr

DIOPT Version :9

Sequence 1:	NP_032117.1	Gene:	Gata3 / 14462	MGIID:	95663	Length:	443	Species:	Mus musculus
Sequence 2:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	132/330 - (40%)
Similarity:	170/330 - (51%)	Gaps:	73/330 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse   135 ASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQD------EKECLKYQVQLPDSM 193
            |:|:|.:|..|:.|:..........|:....|:..|||.||...      .::.:...|.:|.:.
  Fly    34 AASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVGVSGYHQQAVNAPVYVPSNR 98

Mouse   194 KLE-------TSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGS------PTG 245
            :..       ::.::.:.||.|..|:.|..           ||    |.::::.||      |:|
  Fly    99 QYNHVAAHFGSAAAQNAWTTEGFGSAHAQF-----------YS----PNAAVMMGSWRSAYDPSG 148

Mouse   246 FGCKSRPKARSST----EGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRR 306
            |. :|.|...:..    ||||||||||.||||||||||||||||||||||||||.|||||||.:|
  Fly   149 FQ-RSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKR 212

Mouse   307 L---SAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKM 368
            |   :|.||.|..|.||.|.||||||||.:|:|||||||||||||.:||||.|:|:|||||.||.
  Fly   213 LVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKP 277

Mouse   369 SSKS--------------------KKCKKVHDALEDFPKSSSFNPA-ALSRHMSSLSHISPFSHS 412
            ....                    |:||:.||          ..|: :|.||..|..|....|.:
  Fly   278 KKTGSGSAVGAGTGSGTGSTLEAIKECKEEHD----------LKPSLSLERHSLSKLHTDMKSGT 332

Mouse   413 SHMLT 417
            |...|
  Fly   333 SSSST 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gata3	NP_032117.1	Interaction with TBX21. /evidence=ECO:0000269\|PubMed:15662016	1..257		30/140 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PHA03377	<76..260	CDD:177614	30/147 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..180		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214		4/27 (15%)
		ZnF_GATA	262..312	CDD:238123	43/52 (83%)
		Flexible linker. /evidence=ECO:0000250	288..316		21/30 (70%)
		ZnF_GATA	316..366	CDD:238123	37/49 (76%)
		YxKxHxxxRP	344..353		6/8 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..443		2/6 (33%)
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	43/47 (91%)
		ZnF_GATA	168..212	CDD:238123	40/43 (93%)
		ZnF_GATA	223..270	CDD:214648	33/46 (72%)
		ZnF_GATA	226..276	CDD:238123	37/49 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840