DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gart and Gart

DIOPT Version :9

Sequence 1:	NP_001344280.1	Gene:	Gart / 14450	MGIID:	95654	Length:	1010	Species:	Mus musculus
Sequence 2:	NP_001285698.1	Gene:	Gart / 33986	FlyBaseID:	FBgn0000053	Length:	1353	Species:	Drosophila melanogaster

Alignment Length:	1359	Identity:	514/1359 - (37%)
Similarity:	686/1359 - (50%)	Gaps:	382/1359 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISN---AAVSVNDHSALAQFC 62
            |:.||||||||||||.:.|||:|||:|.|:...||:.|.....|..|   ..:...|..|:|::.
  Fly     1 MSHRVLVIGSGGREHAICWKLSQSPKVAQIYALPGSHGIQLVEKCRNLDAKTLDPKDFEAIAKWS 65

Mouse    63 KDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIPTAQWRAF 127
            |:.:|.|||||||.|||.|:...|.|||:.||||..|.||:|:.||:||:||.||.||||::.:|
  Fly    66 KENQIALVVVGPEDPLALGLGDVLQSAGIPCFGPGKQGAQIEADKKWAKDFMLRHGIPTARYESF 130

Mouse   128 TNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSFGAAGETVVVEEF 192
            |:.|.|.:||.||.:|||||||:||||||||:||.:..|||:||.||:.:..:|.||.|:||||.
  Fly   131 TDTEKAKAFIRSAPYPALVVKAAGLAAGKGVVVAANAKEACQAVDEILGDLKYGQAGATLVVEEL 195

Mouse   193 LEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAPQVSKDLLVKIKNTILQR 257
            |||||||.|.|||||:|..|.||||||||.:||.||||||||||||.|.:|:..|..::..:|:|
  Fly   196 LEGEEVSVLAFTDGKSVRAMLPAQDHKRLGNGDTGPNTGGMGAYCPCPLISQPALELVQKAVLER 260

Mouse   258 AVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVMQSTLDGLLS 322
            ||.|:.:|...|.|:||||:|||:|||:||||||||||||.|||||||:|||::||::...|.|.
  Fly   261 AVQGLIKERINYQGVLYAGLMLTRDGPRVLEFNCRFGDPETQVILPLLESDLFDVMEACCSGKLD 325

Mouse   323 ASLPV-WLENHSAVTVVMASKGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDGK-VVTSGGR 385
             .:|: |....|||.|::||.|||...|||..|:|.|.|......|||:|.|:...| .:|:|||
  Fly   326 -KIPLQWRNGVSAVGVILASAGYPETSTKGCIISGLPAANTPTQLVFHSGLAVNAQKEALTNGGR 389

Mouse   386 VLTVTAVQENLMSALAEARKGLAALKF--EGAIYRKDIGFRA--VAFLQRPRGLTYKDSGVDIAA 446
            ||...|:..:|..|.|:|.|...::.|  .||.||.||..:|  :|....| ||:||||||||.|
  Fly   390 VLIAIALDGSLKEAAAKATKLAGSISFSGSGAQYRTDIAQKAFKIASASTP-GLSYKDSGVDIDA 453

Mouse   447 GNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDS 511
            |:.||::|:||::.|.|||....||||.|||.||...:|:|::|..|.|||.|:.:|.....:::
  Fly   454 GDALVQRIKPLSRGTQRPGVIGGLGGFGGLFRLKELTYKEPVIAEATQGVGAKIHLALTHELYEN 518

Mouse   512 IGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPN 576
            :|.||.|:..||:|..||||:.||||.:||||.:.....::.|:|..|:.|.|||:||||||||:
  Fly   519 VGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLVKGMADGCRDARCALVGGETAEMPS 583

Mouse   577 MYPPGEYDLAGFAVGAMER---------------------------------------------- 595
            :|.||::|:||:.||.:|:
  Fly   584 LYAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLIGLPSSGLHCAGFNEILTQLAASKVNLRER 648

Mouse   596 ----------------------------------------------------------------- 595

  Fly   649 SPVDGGDDGLTLAHVLATPTQLYVQQLLPHLQKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDF 713

Mouse   596 ----------------------------------------------------------------- 595

  Fly   714 GAVPVPKIFGWLAGKLKLSAQTILERHNCGIGMVLILPQSSQLWRTSLPGAKVLGVLQRRSKVSG 778

Mouse   596 -------------------------------------------------------------HQK- 598
                                                                         |.|
  Fly   779 SPVQVRNFVEQLEKVASPFGGLGDRELPEELKKLPSNSDLSAPREECFENAAGRRLTRIPTHYKD 843

Mouse   599 ----------------------------------------------------------------- 598

  Fly   844 PILILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLAKEV 908

Mouse   599 -----------------------------------------------LPQLERITEGDAVIGVAS 616
                                                           ||.|:.|..||.:||:.|
  Fly   909 HSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPGDVLIGLPS 973

Mouse   617 SGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGR--VKAFA 679
            ||:||||||||..:::|..|.....||  ..|:|||:.||.||:||..:|..::..|:  :||.|
  Fly   974 SGVHSNGFSLVHAVLKRVGLGLHDKAP--FSDKTLGEELLVPTKIYVKALSTLLSRGKHGIKALA 1036

Mouse   680 HITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEGELSEEEMARTFNCGIGAALVVSKD 744
            |||||||.|||||||.:...|.|||:.:::|.||:||...|.:|..|:.||:|||:|..|||:..
  Fly  1037 HITGGGLSENIPRVLRKDLAVRLDANKFQLPPVFAWLAAAGNISSTELQRTYNCGLGMVLVVAPT 1101

Mouse   745 QAEQVLHDVRRRQEEAWVIGSVVA--CPEDSPRVRVKNLIETIQTNGSLVANGFLKSNFPVQQKK 807
            :.|.||.::|..|..| |:|.|||  .|:.| :|.|:|...::.....:::           |::
  Fly  1102 EVEDVLKELRYPQRAA-VVGEVVARKDPKKS-QVVVQNFEASLARTQKMLS-----------QRR 1153

Mouse   808 ARVAVLISGTGSNLQALIDSTRDPKSSSH--IVLVISNKAAVAGLDRAERAGIPTRVINHKLYKN 870
            .||||||||||||||||||:|||.....|  :|||||||..|.||.||.:||||:.||:||.:.:
  Fly  1154 KRVAVLISGTGSNLQALIDATRDSAQGIHADVVLVISNKTGVLGLQRATQAGIPSLVISHKDFAS 1218

Mouse   871 RVEFDNAVDHVLEEFSVDIVCLAGFMRILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAG 935
            |..:|..:...|:...||::|||||||:||.||||:|.|:::||||||||.:.|.:..:|.||||
  Fly  1219 REVYDAELTRNLKAARVDLICLAGFMRVLSAPFVREWRGRLVNIHPSLLPKYPGLHVQKQALEAG 1283

Mouse   936 VTITGCTVHFVAEDVDAGQIILQEAVPVRRGDTVATLSERVKVAEHKIFPAALQLVASG 994
            ...:|||||||.|.||.|.||:|.|||:...|...:|::|:..|||..||.||.::.:|
  Fly  1284 EKESGCTVHFVDEGVDTGAIIVQAAVPILPDDDEDSLTQRIHKAEHWAFPRALAMLVNG 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gart	NP_001344280.1	PRK00885	4..427	CDD:234856	233/431 (54%)
		AIRS	434..807		174/726 (24%)
		PRK05385	435..766	CDD:235439	164/682 (24%)
		GART	808..1010		104/189 (55%)
		FMT_core_GART	809..991	CDD:187714	103/183 (56%)
		5'-phosphoribosylglycinamide binding. /evidence=ECO:0000250	818..820		1/1 (100%)
		10-formyltetrahydrofolate binding. /evidence=ECO:0000250	896..899		2/2 (100%)
		10-formyltetrahydrofolate binding. /evidence=ECO:0000250	947..951		1/3 (33%)
		5'-phosphoribosylglycinamide binding. /evidence=ECO:0000250	977..980		0/2 (0%)
Gart	NP_001285698.1	PRK00885	4..433	CDD:234856	234/437 (54%)
		GARS_N	4..107	CDD:280931	53/105 (50%)
		GARS_A	108..301	CDD:279419	122/192 (64%)
		GARS_C	337..430	CDD:280930	40/97 (41%)
		PRK05385	442..752	CDD:235439	153/661 (23%)
		PurM	485..752	CDD:100032	130/618 (21%)
		PRK05385	836..1122	CDD:235439	83/161 (52%)
		PurM	840..1123	CDD:100032	80/155 (52%)
		FMT_core_GART	1155..1339	CDD:187714

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850444
Domainoid	1	1.000	251	1.000	Domainoid score	I2099
eggNOG	1	0.900	-	-		E1_COG0151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H637
Inparanoid	1	1.050	700	1.000	Inparanoid score	I670
Isobase	1	0.950	-	0	Normalized mean entropy	S947
OMA	1	1.010	-	-		QHG55216
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003222
OrthoInspector	1	1.000	-	-		oto92730
orthoMCL	1	0.900	-	-		OOG6_100441
Panther	1	1.100	-	-	LDO	PTHR10520
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1035
SonicParanoid	1	1.000	-	-		X2637
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740