Protein Alignment CSK and Cad96Ca

DIOPT Version :10

• Sequence 1: NP_004374.1
• Gene: CSK / 1445
• HGNCID: 2444
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 106/288 - (36%)
• Similarity: 155/288 - (53%)
• Gaps: 28/288 - (9%)

Human   188 WALNMKELKLLQTIGKGEFGDVM---LGDYRGNK----VAVKCIKNDAT---AQAFLAEASVMTQ 242
            |......||....:|:|.||.|.   ..:..||:    ||||.:|..||   .:..|:|..||..
  Fly   463 WEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKS 527

Human   243 LR-HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS----------RGRSVLGGDC-LLKFS 295
            |. |.|:|.|||... :|...:::.||:.:|.|..||||          .|:|.:...| |..|.
  Fly   528 LEPHINVVHLLGCCT-DKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFM 591

Human   296 LDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG-----LTKEASSTQDTGKLPVKWTAP 355
            ..|.:.|:||.....:||||||||:|:::|:..||:|||     :|.:....:..||||::|.|.
  Fly   592 YQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMAT 656

Human   356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420
            |:|.:..||.|||:||||||:|||.:.|..|||.|...||:.:|..||:::.|:.|...:|.:|.
  Fly   657 ESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMY 721

Human   421 NCWHLDAAMRPSFLQLREQLEHIKTHEL 448
            .||..|...||.|.::.:.|:.:...|:
  Fly   722 YCWSHDPQERPLFAEIIQMLDKLLHTEM 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSK	NP_004374.1	Interaction with PTPN22. /evidence=ECO:0000250|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190
		PTKc_Csk	188..443	CDD:133213	105/281 (37%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		PTKc	474..742	CDD:270623	101/268 (38%)