Protein Alignment CSK and Btk

DIOPT Version :10

• Sequence 1: NP_004374.1
• Gene: CSK / 1445
• HGNCID: 2444
• Length: 450
• Species: Homo sapiens
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 441
• Identity: 166/441 - (37%)
• Similarity: 252/441 - (57%)
• Gaps: 26/441 - (5%)

Human    15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSL 79
            :|.|.|......||...|.....::..::: :|:|.|:.:|..|.||:|||:.    ||...|..
  Fly   348 VALYPFKAIEGGDLSLEKNAEYEVIDDSQE-HWWKVKDALGNVGYIPSNYVKP----KALLGLER 407

Human    80 MPWFHGKITREQAERLL-YPPETGLFLVRESTNYPGDYTLCVSC---DGKVEHYRIMYHA-SKLS 139
            ..|:.|.::|::||.|| ...:.|.|:||:|:. .|.|||.:..   ...|:||.|..:| .:..
  Fly   408 YEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYY 471

Human   140 IDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKG 204
            :.|:...|.:..|:.::..::.||..|| |....:..|..........|.::..||.|::.:|.|
  Fly   472 LSEKHCCETIPDLINYHRHNSGGLACRL-KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSG 535

Human   205 EFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTE 267
            :||.|..|.:||: ..|||.:|....:: .|:.||.|||:|:|.|||||.||..:.: .:|||||
  Fly   536 QFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHR-PIYIVTE 599

Human   268 YMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC----EAMEYLEGNNFVHRDLAARNVLVSEDNVA 328
            ||..|||::|||...::::|...||   ||:|    :.|.|||.:|::||||||||.||..:||.
  Fly   600 YMKHGSLLNYLRRHEKTLIGNMGLL---LDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVV 661

Human   329 KVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR 389
            ||:||||.:.....|.|.    |.|:||..||.|...:||:|||||::|:|:|||::.|::||.|
  Fly   662 KVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGR 726

Human   390 IPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL 440
            :...:||.||::|..::.|..|...:|:|||.||......||:|..|.:||
  Fly   727 LKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSK	NP_004374.1	Interaction with PTPN22. /evidence=ECO:0000250|UniProtKB:P41241	9..70		16/54 (30%)
		SH3_CSK	11..67	CDD:212703	16/51 (31%)
		SH2_csk_like	78..175	CDD:198190	29/101 (29%)
		PTKc_Csk	188..443	CDD:133213	117/263 (44%)
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	16/51 (31%)
		SH2_Tec_family	403..505	CDD:198188	30/103 (29%)
		PTKc_Tec_like	521..778	CDD:173637	116/261 (44%)