DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALG10B and Alg10

DIOPT Version :9

Sequence 1:	NP_001013642.2	Gene:	ALG10B / 144245	HGNCID:	31088	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_729680.1	Gene:	Alg10 / 326193	FlyBaseID:	FBgn0052076	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	150/456 - (32%)
Similarity:	227/456 - (49%)	Gaps:	56/456 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    36 MDEIFHLPQAQRYCEGHFSLSQWDPMITTLPGLYLVSVGVVKPAIWIFAWSEHVVCSIGMLRFVN 100
            :||.||:||...:|...|.:  |||.|||.|||||::: ::.|.         .:|::..||.::
  Fly    32 IDEEFHIPQGLAFCRKEFDV--WDPKITTFPGLYLIAL-LLNPL---------SLCTVTGLRMLS 84

Human   101 LLFSVGNFYLLYLLFHKVQPRNKAAS--SIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFA 163
            |..:..|..|||    |::.|..|.|  :.......:|::|.|.||||:.||||:..|:...|..
  Fly    85 LAGAGINILLLY----KIRRRILAGSGGNSYAAHEAITMSVLPPLYFFSHLYYTDTLSLTMVLLF 145

Human   164 YLMCLYGNHKTSAFLGFCGFMFRQTNIIWAVFCAGNVIAQKLTEAW---------KTELQKKEDR 219
            |.......|..:|..|....:.|||||:|.....|..:...|....         ...|..||..
  Fly   146 YNYWQQEAHLPAAVFGAASVLMRQTNIVWVCMATGMTVLDTLVNQCARTGRVPKENVRLMGKELW 210

Human   220 LPPIKGPFAEFRKILQFLLAYSMSFKNLSMLFCLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEA 284
            |..:..|......||..|..            |..:..|:|.|:  .|:.:||.||:||:|:|||
  Fly   211 LQLVSSPQLLCNCILSILAK------------CCFYASIILPFV--GFLFINGSIVVGDKSAHEA 261

Human   285 CLHFPQLFYFFSFTLFFSFPHLLSPSKIKTFLSLVWKHGILFLVVTLVSVFLVWKFTYAHKYLLA 349
            .||.||||||..|...|...:.:  .:.:....|:.::.:|.|:..|:.:.:|...|..|.||||
  Fly   262 SLHVPQLFYFAIFAAGFGISNTI--RQFRPAAELIRRNRVLSLLALLLILVVVHLNTEVHPYLLA 324

Human   350 DNRHYTFYVWKRVFQRYAILKYLLVPAYIFAGWSIADSLKSKPIFWNLMFFICLFIVIVPQKLLE 414
            ||||||||:|.|::.|:...:|.:.|||:.:...:...|:..|..:.|||.:.||:|:..|:|||
  Fly   325 DNRHYTFYIWSRLYGRFWWFRYAMAPAYLLSICVLFCGLRHMPESFKLMFPLSLFLVLCFQRLLE 389

Human   415 FRYFILPYVIYRLNITLPPTSRLV-------CELSCYAIVNFITFYIFLNKTFQWPNSQDIQRFM 472
            .|||::||:::|||      :|..       .||..:.::|..|||::..|.|.|.|.:..||.:
  Fly   390 LRYFLVPYILFRLN------TRHTRKGYAEWLELGAHLLLNVATFYVYFTKEFYWKNYRTPQRII 448

Human   473 W 473
            |
  Fly   449 W 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALG10B	NP_001013642.2	DIE2_ALG10	32..427	CDD:309863	133/401 (33%)
Alg10	NP_729680.1	DIE2_ALG10	29..402	CDD:282739	133/401 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152709
Domainoid	1	1.000	213	1.000	Domainoid score	I2750
eggNOG	1	0.900	-	-		E1_KOG2642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3381
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55092
OrthoDB	1	1.010	-	-		D404988at33208
OrthoFinder	1	1.000	-	-		FOG0004262
OrthoInspector	1	1.000	-	-		otm41735
orthoMCL	1	0.900	-	-		OOG6_103728
Panther	1	1.100	-	-	LDO	PTHR12989
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R37
SonicParanoid	1	1.000	-	-		X3000
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800