DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galnt1 and Pgant9

DIOPT Version :9

Sequence 1:	NP_001153876.1	Gene:	Galnt1 / 14423	MGIID:	894693	Length:	559	Species:	Mus musculus
Sequence 2:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	262/531 - (49%)
Similarity:	340/531 - (64%)	Gaps:	23/531 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    37 KQERGLPAGDVLELVQKP---HEGPGEMGKPVVIPKEDQEKMKEM----FKINQFNLMASEMIAL 94
            :|.:..|..|..:::..|   .|.|||:||||.:|||..::||:.    :..|.||...|::|::
  Fly   122 EQPKKKPQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISV 186

Mouse    95 NRSLPDVRLEGCKTKV-YPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDAS 158
            :|:|||.|...||.:. |..|||.|.|:|.||||||:.||||||||::|||.|:|.:|:||||.|
  Fly   187 HRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYS 251

Mouse   159 ERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGWLEPLL 223
            :...|||.||.|..... .|.:||.::|.||||||:.||..::..|:|:||:|||||.|||||||
  Fly   252 DMPHLKRQLEDYFAAYP-KVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLL 315

Mouse   224 ARIKHDRRTVVCPIIDVISDDTFE--YMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPV 286
            .||..:..|||||:||||||:|.|  |.....:..|||:|.|.|.|:|||:||. :|......||
  Fly   316 DRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERER-KRHNSTAEPV 379

Mouse   287 RTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATP 351
            .:||||||||||||::|..:||||:|.|||||||||:||:.|.||||||||.||||||:|||.:|
  Fly   380 YSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSP 444

Mouse   352 YTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRKLQCKPFSWYLE 416
            |.:..|. .::.||:.|||||||||:..::| ...|..|.|:||:|.|..||..|:||.|.|||:
  Fly   445 YKWRSGV-NVLKKNSVRLAEVWMDEYSQYYY-HRIGNDKGDWGDVSDRRKLRNDLKCKSFKWYLD 507

Mouse   417 NIYPDSQIPRHYFSLGEIRNV--ETNQCLDNMARKENEK--VGIFNCHGMGGNQVFSYTANKEIR 477
            ||||:..||....:.|||||:  ....|||..|.|:::|  ||.:.||..||||.:..:...|||
  Fly   508 NIYPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYWMLSKAGEIR 572

Mouse   478 TDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTG 542
            .||.|||.:  ...||:..||..||||.|.|......|.|..|.:||  |..|......:.:|:.
  Fly   573 RDDSCLDYA--GKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCL--AISESKDKLLMEECSA 633

Mouse   543 SRS-QQWLLRN 552
            |.| |||.|.|
  Fly   634 SLSRQQWTLEN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galnt1	NP_001153876.1	Catalytic subdomain A	115..225		64/109 (59%)
		pp-GalNAc-T	119..419	CDD:133004	171/301 (57%)
		Catalytic subdomain B	285..347		46/61 (75%)
		Ricin_B_lectin	432..548	CDD:306998	48/120 (40%)
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	158/274 (58%)
		pp-GalNAc-T	213..510	CDD:133004	171/300 (57%)
		Ricin_B_lectin	521..640	CDD:279046	48/122 (39%)
		RICIN	523..642	CDD:238092	50/122 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102903
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730