Protein Alignment SLC2A14 and VPS73

DIOPT Version :10

• Sequence 1: NP_001273166.1
• Gene: SLC2A14 / 144195
• HGNCID: 18301
• Length: 535
• Species: Homo sapiens
• Sequence 2: NP_011411.3
• Gene: VPS73 / 852774
• SGDID: S000003072
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 477
• Identity: 133/477 - (27%)
• Similarity: 227/477 - (47%)
• Gaps: 43/477 - (9%)

Human    44 EVTPALIFAITVATIGSFQFGYNTGVINAPETII--KEF--------INKTLTDKANAPPSEVLL 98
            ::|.||.:||.||:|||.||||:...:|||:.::  .||        .::|...|........|.
Yeast    23 KITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGYPYDRTWLGKRGYKQCIPLN 87

Human    99 TNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGR 163
            .....:..::|.:||::||:......|.:||:.|.||...|...|..::   ..:.|...||:||
Yeast    88 DEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGSLII---FNSNSYRGLIIGR 149

Human   164 LVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLG 228
            :::|:.||.....:|::|.|::|:...|..|::.|:.|.:|:|:.|  |:.|.|.....|..:|.
Yeast   150 ILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQ--GIALPLTDSYRWRWILF 212

Human   229 FTILPAILQSAALPCCPESPRFLLINRKKEENATRILQRLWGT--QDVSQDIQ--EMKDESARMS 289
            .:.|.|:|.........|||::||.:.:..: |...|.:|.|.  .:.:|:||  :::.||....
Yeast   213 GSFLIAVLNFFMWFIVDESPKWLLAHGRVTD-AKLSLCKLRGVTFDEAAQEIQDWQLQIESGDPL 276

Human   290 QEKQVT--------VLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQQPIYA 346
            .|...|        :.:..|..:..:...:..||...||..|||::..|.|.|......|..|..
Yeast   277 IEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLFGQQFCGINSIVLYGTKIISQLYPQHAIRI 341

Human   347 TISAGVVNTIFTLLSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILV 411
            .....:||.:.|:|...|:....|:.|.|.....::..:.:|.:::   || |.|:.:.:.: .:
Yeast   342 NFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVSVTAFIMGIAM---NH-NKMNLLIVFS-FI 401

Human   412 FVACFEIGPGPIPWFIVAELFSQGPRPAAMAVAG-----CSNWTSNFLVGLLFPSAAYYLGAYVF 471
            ::..|.:|..|:|:.|:.|:    .:|..|.:|.     | ||...|::...||.....|..|||
Yeast   402 YMGVFTMGLNPLPFIIMREV----SKPQDMVLAQRYGTIC-NWVGTFIIAYTFPIIHDVLSGYVF 461

Human   472 IIFTGFLITFLAFTFFKVPETR 493
            |||.....:..||.:.|||||:
Yeast   462 IIFAIIACSISAFIWKKVPETK 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A14	NP_001273166.1	MFS_GLUT_Class1	51..495	CDD:340989	130/470 (28%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	130/469 (28%)