DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC2A14 and Glut1

DIOPT Version :10

Sequence 1:NP_001273166.1 Gene:SLC2A14 / 144195 HGNCID:18301 Length:535 Species:Homo sapiens
Sequence 2:NP_612073.2 Gene:Glut1 / 38109 FlyBaseID:FBgn0264574 Length:1440 Species:Drosophila melanogaster


Alignment Length:487 Identity:235/487 - (48%)
Similarity:317/487 - (65%) Gaps:12/487 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    47 PALIFAITV----ATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVA 107
            |.|.|.:|.    |.:|..|||||||||||||..|:.|:.....|:.....||..:..|:|::|:
  Fly     7 PGLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVS 71

Human   108 IFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGL 172
            ||::|||:|.||.|...|||||:..:|:.|:|...|.||||..|::.|.|||.|||.:||:.|||
  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGL 136

Human   173 CTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQ 237
            .|..|||||.||:|..|||..||:|||.:.:|:|::|:.|:|.|||:.|.||:|||..|.|||||
  Fly   137 NTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQ 201

Human   238 SAALPCCPESPRFLLINRKKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRV 302
            ...||.||||||:|||.::.||.|.:.|:||..:..|.:||:||:.|......|..::.:||...
  Fly   202 LILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICS 266

Human   303 SSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGV--QQPIYATISAGVVNTIFTLLSLFLV 365
            .:.|.|:||.||:|||||.|||||||||||.:|..:|:  :...:|||..|.:..:.||:|:.|:
  Fly   267 PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLM 331

Human   366 ERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAE 430
            :|.||||||:.|||||...|..:|:|.|:|...:.||::.:.|.|.||..|.:|||.|||.|.||
  Fly   332 DRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAE 396

Human   431 LFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGR 495
            ||||||||:|||:|...||.:||:||:.|||....|..|.|:.|:.||..|..||:.|||||:.:
  Fly   397 LFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNK 461

Human   496 TFEDITRAFEGQAHGADRSGKDGVMGMNSIEP 527
            |||:|...|.      ..:|:..:...||:||
  Fly   462 TFEEILALFR------HNNGRSMLNCTNSLEP 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC2A14NP_001273166.1 MFS_GLUT_Class1 51..495 CDD:340989 223/449 (50%)
Glut1NP_612073.2 MFS_GLUT_Class1 15..461 CDD:340989 221/445 (50%)

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