DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRICKLE1 and RGA1

DIOPT Version :10

Sequence 1:NP_694571.2 Gene:PRICKLE1 / 144165 HGNCID:17019 Length:831 Species:Homo sapiens
Sequence 2:NP_014770.1 Gene:RGA1 / 854294 SGDID:S000005653 Length:1007 Species:Saccharomyces cerevisiae


Alignment Length:681 Identity:135/681 - (19%)
Similarity:234/681 - (34%) Gaps:166/681 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   189 PRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQR--YIMKDGRPFCCGCFESLYAEYC 251
            |.|..|.|.|......|.....||...|.|.:||..|..:.  .::..|...|..|.:|     |
Yeast    11 PSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDS-----C 70

Human   252 ETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASD 316
            :.||:.|. |.|.:.......:.:: ||.|.:|..::....:...:..::|.             
Yeast    71 KNCGKKID-DLAIILSSSNEAYCSD-CFKCCKCGENIADLRYAKTKRGLFCL------------- 120

Human   317 SSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADD-TLSRKLDDLSL 380
            |......:.|.....:..|:.|:..|        |.:|.::      :|:.|: :.|..|.:.:.
Yeast   121 SCHEKLLAKRKYYEEKKRRLKKNLPS--------LPTPVID------NGHTDEVSASAVLPEKTF 171

Human   381 SRQGTSFASEEFWKGRVEQETPEDPEEWADHEDYMTQLL----------------LKFGDK---S 426
            ||..:           :..|.|...|...|.|...:.::                .|||..   .
Yeast   172 SRPAS-----------LVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSID 225

Human   427 LFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGP 491
            :..|:.|     ::|| ::|: ||.:.|....|.||               :...|........|
Yeast   226 VIGPEEN-----STEH-VNDD-VKEEAEAPSANMSL---------------NVATDPTLSCKEPP 268

Human   492 ASSRR-LQELELDHGASGYNHDETQWY------EDSLECLSDL-KPEQSVRDSMDSLALSNITGA 548
            :.||. |.:..|.:.:..|.......|      .||||....: .|..|.|::.:.|.....:..
Yeast   269 SHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPV 333

Human   549 SVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKP 613
            ||:.:| |:.|...:.|..|:...|       .:|:..:|:...|...:|...:.  :::.|::.
Yeast   334 SVNMKN-PKGSNTDIFNTGEISQMD-------PSLSRKVLNNIVEETNALQRPVV--EVVKEDRS 388

Human   614 VHLPVL---------------------RRSKSQSRPQQVKFSDDVIDN------GNYDIEIRQPP 651
            |  |.|                     :.|:|.||.     |.|::.|      |..|..::..|
Yeast   389 V--PDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRR-----SKDLMINLKSRATGKQDSNVKLSP 446

Human   652 MSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNK 716
            .|:.|.||..:. .|.:.||......:..|.|   |:::...:.|.          ||::|..|.
Yeast   447 ASKVTSRRSQDL-MRDNDSHTGLDTPNSNSTS---LDILVNNQKSL----------NYKRFTDNG 497

Human   717 SAREIQAYIQNADLYGQYAHATS-----DYGLQNPGMNRFLGLYGED--DDSWCSSSSSSSDSEE 774
            :.|....  :...|..|..|:..     |:.||:|.....:.:|...  |.|......:.|....
Yeast   498 TLRVTSG--KETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSN 560

Human   775 EGYFLGQPIPQPRPQRFAYYTDDLSSPPSAL 805
            :.|.:  |..|..|:.....:|:.......|
Yeast   561 QNYSI--PSWQKTPKTQLENSDNFEEQKETL 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRICKLE1NP_694571.2 PET_Prickle 22..118 CDD:193602
LIM1_Prickle_1 126..184 CDD:188867
LIM2_Prickle 189..244 CDD:188802 16/56 (29%)
LIM3_Prickle 249..307 CDD:188804 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..342 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 663..688 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..831 7/43 (16%)
RGA1NP_014770.1 LIM1_Rga 13..67 CDD:188780 14/53 (26%)
LIM2_Rga 70..123 CDD:188781 12/67 (18%)
RhoGAP 803..1002 CDD:214618
Blue background indicates that the domain is not in the aligned region.

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