Protein Alignment PRICKLE1 and prickle1

DIOPT Version :10

• Sequence 1: NP_694571.2
• Gene: PRICKLE1 / 144165
• HGNCID: 17019
• Length: 831
• Species: Homo sapiens
• Sequence 2: XP_012814522.1
• Gene: prickle1 / 549693
• XenbaseID: XB-GENE-486941
• Length: 871
• Species: Xenopus tropicalis
• Alignment Length: 838
• Identity: 675/838 - (80%)
• Similarity: 750/838 - (89%)
• Gaps: 12/838 - (1%)

Human     1 MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGE 65
            |||||:.|:||..||||||||||||||||:|||.||||||||||:|||||||||.|||||||.||
 Frog    39 MPLEMDQKISKHTFGCQRSSTSDDDSGCAMEEYTWVPPGLRPEQVQLYFACLPEAKVPYVNSVGE 103

Human    66 KHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCG 130
            |.|||||||||||||||||||||||||||||||:|||||||||||||.||:||||||||:||:||
 Frog   104 KCRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQMFSAQRKKEALGRGNIKMLSRAVMHAMCEKCG 168

Human   131 LKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACD 195
            .||||||:|:|.||||||||||||||||.||||||||||||||||||||||||||||||||||||
 Frog   169 EKINGGEIAIFVSRAGPGVCWHPSCFVCSTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACD 233

Human   196 EIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGV 260
            ||||||||||||||||||.||.|.||||||||||||||||||||||||||.||||||:|||||||
 Frog   234 EIIFADECTEAEGRHWHMNHFSCYECETVLGGQRYIMKDGRPFCCGCFESHYAEYCESCGEHIGV 298

Human   261 DHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSA 325
            ||||||||||||||||.||||||||.||||||||||:|:|||||.||||||||||||||||||||
 Frog   299 DHAQMTYDGQHWHATETCFSCAQCKVSLLGCPFLPKKGRIYCSKACSLGEDVHASDSSDSAFQSA 363

Human   326 RSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASE 390
            |||:|||||||||||||||||||||||||||||||||:|||||||||||:||||:||||..| ..
 Frog   364 RSRESRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGMSGNADDTLSRKMDDLSISRQGAGF-DN 427

Human   391 EFWKGRVEQETPEDPEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTEL 455
            :|||.|.|||||||.||||:|:|||||||||||:|.|||..|.  |.|::|||:||| :|.|.:|
 Frog   428 DFWKARDEQETPEDHEEWAEHDDYMTQLLLKFGEKGLFQQAPE--DNRSNEHWMSDN-IKGKNDL 489

Human   456 KQN--NQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYE 518
            ::|  |||||||||||||||||||||||||||||||||||||:||||::|||||||.|::..||:
 Frog   490 QRNSRNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRKLQELDMDHGASGYMHEKMPWYK 554

Human   519 DSLECLSD-LKPE-QSVRDSMDSLALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMG 581
            .||||||| |||: :::.|||||||||||||||||.||||||||:|.|||:::.|.|||||||||
 Frog   555 RSLECLSDNLKPQNENICDSMDSLALSNITGASVDRENKPRPSLFSYQNFQDLNTRDCEKMSNMG 619

Human   582 TLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNY-DI 645
            |||||||:||.||||||:||:|.||..|||||:|...|||||||:|| ||||||||||||:. .|
 Frog   620 TLNSSMLNRSTESLKSLNSEICQEKPPPEEKPMHTSALRRSKSQTRP-QVKFSDDVIDNGDCGSI 683

Human   646 EIRQPPMSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDR-LRLYTPDNY 709
            :|||||||||:||||||||||..|.||||||:||||||:|||:|.||.|.|.::| .|.||.::|
 Frog   684 DIRQPPMSERSRRRVYNFEERSQRPHHHRRRKSRKSRSENALHLATESKPSGRERNPRFYTAEDY 748

Human   710 EKFIQNKSAREIQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSS-SSSSSDSE 773
            ||...|:||.|:|||||||||:|||.:|.|::||.:..:::||||||||:|||||: ||||||||
 Frog   749 EKLFHNRSAHEVQAYIQNADLFGQYPNAASNFGLPSQVVDKFLGLYGEDEDSWCSTCSSSSSDSE 813

Human   774 EEGYFLGQPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS 831
            |||||||||||:|.|||:.|::|||.||.:||.:.||.||||||||||||||||||||
 Frog   814 EEGYFLGQPIPKPLPQRYQYFSDDLCSPTNALSSSQFSQRTTKSKKKKGHKGKNCIIS 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE1	NP_694571.2	PET_Prickle	22..118	CDD:193602	86/95 (91%)
		LIM1_Prickle_1	126..184	CDD:188867	51/57 (89%)
		LIM2_Prickle	189..244	CDD:188802	51/54 (94%)
		LIM3_Prickle	249..307	CDD:188804	51/57 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..342		27/28 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..688		19/24 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..831		53/68 (78%)
prickle1	XP_012814522.1	PET_Prickle	60..156	CDD:193602	86/95 (91%)
		LIM1_Prickle	164..222	CDD:188799	51/57 (89%)
		LIM2_Prickle	227..282	CDD:188802	51/54 (94%)
		LIM3_Prickle	287..345	CDD:188804	51/57 (89%)