Protein Alignment PRICKLE1 and esn

DIOPT Version :10

• Sequence 1: NP_694571.2
• Gene: PRICKLE1 / 144165
• HGNCID: 17019
• Length: 831
• Species: Homo sapiens
• Sequence 2: NP_001260760.1
• Gene: esn / 53557
• FlyBaseID: FBgn0263934
• Length: 1134
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 305/842 - (36%)
• Similarity: 413/842 - (49%)
• Gaps: 221/842 - (26%)

Human    17 QRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDN 81
            ||:|.||||||||||||.||||||||:|::|||:.||::|||||||||||:|:||||:||||.||
  Fly   487 QRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQDN 551

Human    82 EVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAG 146
            |||||.|||:||:|||::||||||:||||||.::|||.   ...|:.|...::||::.|||.|.|
  Fly   552 EVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSD---ERPCKGCEEPLSGGDIVVFAQRLG 613

Human   147 PGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHW 211
            ..:||||.||||..|.|||||||||.:||.::|||||||..||||||||||||:|||||||||.|
  Fly   614 AQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTEAEGRTW 678

Human   212 HMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATE 276
            |||||.|.|||..||||||||::|:|:|..||::::||||:.|||.||||..||::||||||||:
  Fly   679 HMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQHWHATD 743

Human   277 ACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDS-----AFQSARSRDSRRSVRM 336
            .||||..|:.||||.||||::|.||||..||.||....||:|..     ..:::.|....:|.|.
  Fly   744 QCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPTPSDTSSGPQLRPTHRASTSSQIAKSPRR 808

Human   337 GKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQET 401
            | ..|..|..|::       ::..|..:|:|.|.|.|:      .||            |:|...
  Fly   809 G-GERERDPGRKA-------HHGHPKATGSAGDLLERQ------ERQ------------RMEAAG 847

Human   402 PEDPEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKK 466
            ..|             |||..|...:  |:|
  Fly   848 VAD-------------LLLGGGVPGM--PRP---------------------------------- 863

Human   467 YQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQ 531
                                :||.|.....| .:.||:..:|    :...:.|:          |
  Fly   864 --------------------AHPPPIDLTEL-GISLDNICAG----DKSIFGDT----------Q 893

Human   532 SVRDSMDSLALSNITGA----SVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSA 592
            ::.:||..:.||....:    |:|..|...||                        ||.:...:.
  Fly   894 TLTNSMPDMLLSKADDSHSYQSIDKINLNSPS------------------------NSDLTQSTQ 934

Human   593 ESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTR 657
            |....|..:..|.:.||.:.  :..:...:::|..|.: ::.|:.:||         .||.|
  Fly   935 ELANELELDNEPVRELPHDG--YEQLFANNRNQEHPAE-QYDDEQLDN---------RPMKE--- 984

Human   658 RRVYNFEERGSRSHHH------RRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNK 716
            .|.::.::..|||..:      ||||.|::                                |::
  Fly   985 VRFHSVQDTMSRSKSYTDNSNARRRRRRRN--------------------------------QSR 1017

Human   717 SAREIQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLGQ 781
            |:.|:|....|..|:    :|.:..|  ...:|....|...|..|.||:.||||.|:.:.|....
  Fly  1018 SSSEMQINQTNLRLH----NAQTQVG--TTPLNLLNNLDNCDVASICSTCSSSSSSDMDDYVYRL 1076

Human   782 P------------IPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS 831
            |            :|.   ...||......:..|:| .|..|..:........|:.|||.||
  Fly  1077 PARKHYGGVRVAYVPN---DALAYERKKKMAQDSSL-APGAGNASVGGAPAIMHESKNCTIS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE1	NP_694571.2	PET_Prickle	22..118	CDD:193602	74/95 (78%)
		LIM1_Prickle_1	126..184	CDD:188867	33/57 (58%)
		LIM2_Prickle	189..244	CDD:188802	42/54 (78%)
		LIM3_Prickle	249..307	CDD:188804	38/57 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..342		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..688		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..831		20/79 (25%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	74/95 (78%)
		LIM1_Prickle	593..651	CDD:188799	33/57 (58%)
		LIM2_Prickle	656..711	CDD:188802	42/54 (78%)
		LIM3_Prickle	716..774	CDD:188804	38/57 (67%)