DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and Gad1

DIOPT Version :9

Sequence 1:	NP_032103.2	Gene:	Gad1 / 14415	MGIID:	95632	Length:	593	Species:	Mus musculus
Sequence 2:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	285/501 - (56%)
Similarity:	366/501 - (73%)	Gaps:	11/501 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse    97 LFAQDLLPAK-NGEEQTAQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDH 160
            |.|.||:|.. ....:|.:|||:|:|:||::|:.|.||:.||||||||..:...::   |::.|.
  Fly    17 LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLD---LDVPDR 78

Mouse   161 PESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLME 225
            ...|:|::.||..||||.|:||||.||||||.|||:|.:||||||:|||||||||||||||:|||
  Fly    79 ALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILME 143

Mouse   226 QITLKKMREIVGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEHS 289
            .:.|.|||||:|||.  ||.|.:|||:|||:|:.:|||:|.||..|..|...:| .||:|||:..
  Fly   144 NVVLTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQC 206

Mouse   290 HYSIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGYVPLYVNATAGTTVYGAFDP 354
            |||||...|..|.|||:.|::..:|.||:|.::||..||:.|.||.:|.:|||||||||.||||.
  Fly   207 HYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDD 271

Mouse   355 IQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLSGIERANSVTWNPHKMMGVLLQCSAILVK 418
            |..|||||:|||.|:|:|||||||||||||||| :.:|:|||:||||||||:||.|||||.|..|
  Fly   272 INTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFK 336

Mouse   419 EKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCL 483
            |.|:|..||||.|.|||..|||||:|||||||.||||||.||||.||.|:||||.|||.|.::.:
  Fly   337 EDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLM 401

Mouse   484 ELADYLYAKIKNR-EEFEMVFDGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMME 547
            ||..|...:|:.: :.|.::.  |||..||.|||:|:.|||||...::..:|.::.|.||..||:
  Fly   402 ELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMMQ 464

Mouse   548 SGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL 593
            .||.||||||...:.||||.:||:.|..::|:||:::||.|||.||
  Fly   465 KGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_032103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:365998	223/376 (59%)
		Substrate binding. /evidence=ECO:0000250	189..191		1/1 (100%)
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	220/372 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835051
Domainoid	1	1.000	468	1.000	Domainoid score	I459
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H635
Inparanoid	1	1.050	591	1.000	Inparanoid score	I980
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm42962
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4534
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790