DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and b

DIOPT Version :9

Sequence 1:	NP_032103.2	Gene:	Gad1 / 14415	MGIID:	95632	Length:	593	Species:	Mus musculus
Sequence 2:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	244/545 - (44%)
Similarity:	354/545 - (64%)	Gaps:	17/545 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    53 TNSLEEKSRLVSAFRERQSSKNLLSC--ENSDQGARFRRTETDFSNLFAQDLLPAKNGEEQTAQF 115
            |:|..:.:..| ||  .|:||.|.:.  .|::.......|:.|.|:..|..  ||...|    .|
  Fly    44 TSSPADSTSTV-AF--EQASKMLANAANNNNNNNNNITSTKDDLSSFVASH--PAAEFE----GF 99

Mouse   116 LLEVVDILLNY-VRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV 179
            :...||.::.. |.:..:||:||:::|.|.:|   .:.|:.:|.:..||.:::....|:|:::.|
  Fly   100 IRACVDEIIKLAVFQGTNRSSKVVEWHEPAEL---RQLFDFQLREQGESQDKLRELLRETIRFSV 161

Mouse   180 RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSN-KDG 243
            :||||.|.|||.:|:|...|.|:|||...|.:::|||:||:|.|||:..|.:||.|||:.| ..|
  Fly   162 KTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQG 226

Mouse   244 DGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEHSHYSIKKAGAALGFGTDNVI 308
            ||||.|||:|:|.|:|..|||::.||.|..|:.....|::||||.:|||::|....:|||:|:|.
  Fly   227 DGIFCPGGSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVR 291

Mouse   309 LIKCNERGKIIPADLEAKILDAKQKGYVPLYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDA 373
            .|..||.||:..:|||.::....:.|:.||.|:|||||||.||||.:..|:::|:|||:|:||||
  Fly   292 KIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDA 356

Mouse   374 AWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPD 438
            |||||.|||:|:||.|:|||||:||||||||::....|||..|.:.:.:|..|:...|.||||.|
  Fly   357 AWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKD 421

Mouse   439 KQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELADYLYAKIKNREEFEMVF 503
            |.||.|:|||||.|||||..|:||||.|||||||.|.|..:.|...:|::..||::.|..||:|.
  Fly   422 KFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVL 486

Mouse   504 DGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMMESGTTMVGYQPQGDKANFFRMV 568
            : .||.||:.|||:|..||.:..:.|..::||:||||:|..|::.|:.|:.|||.....||||:|
  Fly   487 E-SPECTNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLV 550

Mouse   569 ISNPAATQSDIDFLIEEIERLGQDL 593
            :.|....:||:.:.::|||.|.|:|
  Fly   551 LQNSCLEESDMVYFLDEIESLAQNL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_032103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:365998	186/374 (50%)
		Substrate binding. /evidence=ECO:0000250	189..191		1/1 (100%)
b	NP_001246025.1	AAT_I	128..499	CDD:302748	186/374 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910