DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a13 and CG8850

DIOPT Version :9

Sequence 1:	NP_001366036.1	Gene:	Slc6a13 / 14412	MGIID:	95629	Length:	602	Species:	Mus musculus
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	205/549 - (37%)
Similarity:	311/549 - (56%)	Gaps:	23/549 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 TSNGETKPV-CPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFI 72
            ::.||...: |.|    |.:.:.:|:.|:..:||:.|.....:|||||||||::..:||||||.|
  Fly    37 SAEGEELTINCEA----ESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLI 97

Mouse    73 PYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWAL 137
            ||:|.|...|.||::||..:||::::|.|.|: .:.||..||.|......:|...||..::|..:
  Fly    98 PYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACIMALTI 161

Mouse   138 FYLFSSFTTDLPWGSCSHEWNTENCVE--FQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQH 200
            .||.:||:..|||..|..||. ::||.  ...||||..|   ...|....|:.:.||:..:.:..
  Fly   162 RYLVASFSEVLPWTYCLVEWG-KSCVATGATAANDSSIV---QGVSSAELFFTQTVLREPESLDD 222

Mouse   201 --LGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQ 263
              ||:..|:||||||..|:|....:.||::|:||..||.|.|||::::|||||.||||||.|||.
  Fly   223 NGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAWQGIV 287

Mouse   264 FYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMA 328
            ::|.|..::|.:|.||..|.||:|||.|||.|.|....|:|.::.|.::|.|.:..::|.||.:|
  Fly   288 YFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLTSILA 352

Mouse   329 GFAIFSILGFMSQEQGV-PISEVAESGPGLAFIAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQ 391
            |..||.|||.::.|... .||:|.:.|.|||||:||.|:....:.| |:|..||||:::||:.|.
  Fly   353 GCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLGIGSN 417

Mouse   392 FVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCL 456
            .....::|..:.|.:..:     ...:|.:..|:|.|..||:.:|.||.:|..|.|:|..:.:.|
  Fly   418 IGMASAVVNVVKDRFTHL-----PHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIAL 477

Mouse   457 LFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYN 521
            : :||.|.|.|.|:||..|...:||.|:..|.....:.||....|.:.....::.|..|.||||
  Fly   478 V-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTY- 540

Mouse   522 KKYTYPWWGDALGWLLALSSMICIPAWSI 550
            :...||......||::....::.:|.|::
  Fly   541 RGVQYPPVYYMAGWIIWGLGVLQLPFWAL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a13	NP_001366036.1	SLC5-6-like_sbd	32..575	CDD:382020	200/525 (38%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	187/484 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820