DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a12 and CG8850

DIOPT Version :9

Sequence 1:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	216/574 - (37%)
Similarity:	321/574 - (55%)	Gaps:	39/574 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 DGYPVVSWVPEEGEMMD---QKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGG 85
            ||...|.: ..|||.:.   :...:....|.||:..:||:.|.....:|||||||||::..:|||
  Fly    29 DGISTVIY-SAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGG 92

Mouse    86 GAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIII 150
            |||.|||.|.....|.||::|||.:||:||:|.:.|: .:.|:::||....|...:....||..|
  Fly    93 GAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAF-DMAPIMRGIAYGQVYSTALATTYYACI 156

Mouse   151 LAWALFYLFSSFTWELPWTTCTNSWNTEHCV----DFLNHSS-ARGVSSSENFTSPVMEFWERRV 210
            :|..:.||.:||:..||||.|...|. :.||    ...|.|| .:||||:|       .|:.:.|
  Fly   157 MALTIRYLVASFSEVLPWTYCLVEWG-KSCVATGATAANDSSIVQGVSSAE-------LFFTQTV 213

Mouse   211 LGITSGIHD--LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVT 273
            |.....:.|  ||:..|:|.||||..|:|....:.||::|:||..||.|.|||:::|:||||.||
  Fly   214 LREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVT 278

Mouse   274 LPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCF 338
            ||||:||||::|||...:|.:|.||..|.||:|||.|||.|.|....|:|.::.|.::|.|.:..
  Fly   279 LPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITT 343

Mouse   339 LNSATSFVAGFVVFSILGFMSQEQGI-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIM 401
            ::|.||.:||.::|.|||.::.|... .||:|.:.|.|||||::|:|:.... |.||::.|||.|
  Fly   344 IDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFM 408

Mouse   402 LLFLGLDSQFVCMECLVTASMDMF---PQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQ 463
            ||.||:.|.......:|....|.|   |..        ||.::.|::.:|.||:.:|.||.::..
  Fly   409 LLVLGIGSNIGMASAVVNVVKDRFTHLPHW--------LLAVSASIIGFLCGLVYMTPGGQFVLN 465

Mouse   464 LFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFF 528
            |.|:|..:.|.|: |::.|::.:||:||..|...::|.|:..:.....:|.|..:.|||......
  Fly   466 LVDFYGCTFIALV-LAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLV 529

Mouse   529 FSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFL----KTQGS 578
            :.|..|.||.|..| .||...|..||::....:..:|.:.::|..    ||.||
  Fly   530 YMLFSYEPLTYRGV-QYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	210/546 (38%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	192/491 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820