DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a12 and CG15279

DIOPT Version :9

Sequence 1:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus
Sequence 2:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	213/584 - (36%)
Similarity:	327/584 - (55%)	Gaps:	44/584 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 DQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVF 104
            ||:.....::|..|...:||::|.....:|||||||||:....||||||.|||.|..|..|.|::
  Fly    40 DQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIY 104

Mouse   105 FLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWT 169
            :||:.:||:||:|||..: .:||.::|:|.........|:.||..::|....|...||...|||:
  Fly   105 YLEMVIGQFSSRGSVKVF-DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWS 168

Mouse   170 TCTNSWNTEHCV----DFLNHSSARGVSS-SENFTSPVMEFWERRVLGITSG--------IHD-- 219
            ||...|.. ||:    |..|.|....... .:|:|   |:....||  |||.        :|:
  Fly   169 TCRAEWGI-HCINSAPDASNWSQLESNDQRPQNYT---MKSQNDRV--ITSSEWYFVKEVLHEKP 227

Mouse   220 -----LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQ 279
                 :|...|||.:.|.:||...:|.|.:||||:||..||.|.|||:::.:||:|.|||||:..
  Fly   228 NIEEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSID 292

Mouse   280 GIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATS 344
            ||.:::||...::.||:||..|.||.|:|.::|.|.:....|:||:.:|.:||:..:..|::.||
  Fly   293 GIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTS 357

Mouse   345 FVAGFVVFSILGFMSQEQGI-PISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLLFLGL 407
            .:|||.:|.|||.::.|.|. .|..|.:.|.|||||::|.|:.... |.|::|.|||:||..||:
  Fly   358 LLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGI 422

Mouse   408 DSQFVCMECLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSG 472
            .|......|.|||..|.||    ..|:.:..:| |:|:.:.:||:.:|.||.|:..|.|::.:|.
  Fly   423 GSNIAMTSCSVTAIRDRFP----NFGQWQCSLL-IAVVSFFIGLMYITPGGQYMLTLVDFFGASM 482

Mouse   473 ICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPL 537
            |.|: |.:.|:..|||:||.||...::|.|:|.:.....::.|..:||.:......:..:.|.||
  Fly   483 IALV-LGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPL 546

Mouse   538 KYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQG-SFKKRLRRLITP-------DPSL 593
            .|||: :||:|.||||||:....:..:|:::|:..::..| :...::|...||       ||.|
  Fly   547 TYNNI-VYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNWGPSDPLL 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	206/562 (37%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	206/561 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820