Protein Alignment PLEKHA7 and kmr

DIOPT Version :9

• Sequence 1: XP_024304124.1
• Gene: PLEKHA7 / 144100
• HGNCID: 27049
• Length: 1365
• Species: Homo sapiens
• Sequence 2: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Alignment Length: 1685
• Identity: 336/1685 - (19%)
• Similarity: 572/1685 - (33%)
• Gaps: 562/1685 - (33%)

Human    73 IDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQ--------RPSSMVSETSTAGTA 129
            :...||....::.:....|...:.:|.|..||..:::..:.|        .|||  .|:|:..|.
  Fly   278 LQQQQQQHRHKNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSS--EESSSNSTK 340

Human   130 STLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCL 194
            |...|....|  ||:..:.:.  :....:|.|:.||.:.||||||.|.|:::|::||||||:|||
  Fly   341 SPSHAPLDRK--KSAGSIQAL--KSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCL 401

Human   195 FYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRT 259
            :|||...||.:|||:.||||.:|...|||:|.||::||..|                   ..|||
  Fly   402 YYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEH-------------------QNMRT 447

Human   260 YYFSADTQEDMNAWVRAMNQAAQVLS----------RSSLKRDMEKVER------------QAVP 302
            |:.:||..|.|..||||:..|:.:.:          .|||....|..:.            |..|
  Fly   448 YWLAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQPTP 512

Human   303 QANHTESCHECGRVGPG-----HTRDCPHRGHD---DIVNFERQEQEGEQYRSQR--DPL----- 352
            .:.:|.|  ..|..|.|     :....|.|.:|   ...:.|..||: :|:.|:|  .|.
  Fly   513 SSENTGS--SGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQ-QQHPSRRLMSPTQQLYQ 574

Human   353 EGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKN---GMLPASYGPGEQNGTGGYQR 414
            :.:..||:.:....|.:..|:: |..||......|.|:|::.   ..|.|.:...:.:......|
  Fly   575 QQQHQRSQQQQQQQPQQHHAIY-DTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIAR 638

Human   415 AFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTL---PRQGP---GQS--------LS 465
            ....|...|.:.:|:..:|::   .:.::|.:.:.|..|.|   .|:.|   |:|        .:
  Fly   639 LQQQRAAEEIYGEREMYMAKL---MQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAA 700

Human   466 FPENYQTLPKSTRHPSGGSSP-------------------PP-----RNLPS-DYKYAQDRASHL 505
            ...:|:.:...::...||..|                   ||     :::|: ..:|.   .:||
  Fly   701 AAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYT---PNHL 762

Human   506 KMSSEER-------RAHRDGTVWQ-----LYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSML 558
            :.|:.::       ||.....:.:     ..|::.|.:....:..|.:.....|.....|.:|.|
  Fly   763 EASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSL 827

Human   559 EVPR------------------------------------------------------------- 562
            ::.|
  Fly   828 DINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYER 892

Human   563 ---------------SISVP------------------PSPSDIPPPG--PPRVFPPRRPHTPAE 592
                           :.|:|                  |...|:||..  |..:||   |....:
  Fly   893 AYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFP---PSMSTQ 954

Human   593 RVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSL 657
            .:..|.....||....|   |:|:.|.....|:.....:.|:.|.........:|.|:...|.|:
  Fly   955 EIISKNEQFLRSASARL---PKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESM 1016

Human   658 L-------------LTRLRRHQ--------AKLASVRNFAISQLLQHQLTFPTCQADDTYLQLKK 701
            .             |||....|        :||.|..|..::............||..|.|
  Fly  1017 KRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVL---- 1077

Human   702 DLEYLDLKIKN---------NEPLINVLYKVLKKSARGCRP------------------------ 733
                    :.|         |.|..:.:.:...:|.....|
  Fly  1078 --------VGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYS 1134

Human   734 ---RRSMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKEN---------K 786
               .||.:.:...|..:.:.: :|.:...:.::.......:....:.:..|...:         |
  Fly  1135 ATAGRSSSSKTTTKATTSQAI-VATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAK 1198

Human   787 DQLESVLEVLHRQMEQ--YRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLE 849
            .||:.:|:| |...:.  .:.||:|||:   :.||        |.:|.:             .:.
  Fly  1199 FQLKPILKV-HEASKTRIIQVQPKHLEE---RPKL--------RLQLPK-------------AMG 1238

Human   850 NDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESV--KNPERKT-V 911
            |:.|| ||..:||                    |:|.|      |...||.:..  |:|:... |
  Fly  1239 NEEEQ-KQEDEEQ--------------------ENVEA------EPVPILPKKTAPKSPQNANYV 1276

Human   912 PLFPHPPVPSLSTSE-SKPPPQPSPP------TSPVRTP--LEVRLFPQLQTY------------ 955
            |::.:..|.:....| .||.|:...|      |.|..||  ::::||.:.|..
  Fly  1277 PVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDL 1341

Human   956 ---VPYRPHP-------PQLRKVTSPLQSPTKAKPKVQEDEAPPRPPLPELYSPEDQPPAVPPLP 1010
               ...:|.|       |::.| ...|:|..:.:....||::    ...|.|:.:|...|:....
  Fly  1342 TPTAESKPIPGEEDMGAPKVIK-DQKLESNEEEQELEDEDDS----TACEEYTDDDIDEALAQDD 1401

Human  1011 REATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEP--------------ELATL 1061
            .:..::...       :|.|...:|||.|.           ||:||              .:...
  Fly  1402 EDEAVVEAV-------ESQELAEERELQQI-----------YVNEPITPTDQQFDESHYLPMTPK 1448

Human  1062 SGDMAQPS-LGLVG-------PESRYQTLPGRGLSGSTSR-------LQQSSTIAPYVTLR---- 1107
            ..::.||. |.||.       .|:.|..:. :|:.....|       |..:|:.|..||.:
  Fly  1449 KVELGQPGVLTLVSATYAEEEEENHYVEMT-KGIQDEDCRSNYEIMCLASTSSSAFKVTTKTEPV 1512

Human  1108 ----RGLNAESS------------KATFPR-PKSALERLYSGDHQR-GK---------------- 1138
                .|:.|.|:            ::|..: .||..|.|.....:| ||
  Fly  1513 YMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILKPAKSALALA 1577

Human  1139 ---MSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYL--SRPL----------------- 1181
               ..|:::..|.:...|.|   |.|:......|..|:|.||  |.||
  Fly  1578 SDSSDADDESSRQQLEAKKL---RSRSRFSLSDTFRPASYYLGASTPLNNYAESSDSEILPPPPI 1639

Human  1182 ---PGDLGSWKREQDFDLQLLERVVQGEKKDKEENGW--LKVQAMPVTELDLEPQDYDLDISREL 1241
               |..:...|.|:.|..:..:.|     |.|:.||.  |..:.:|    .:...:..|::.:.:
  Fly  1640 PASPPPMEELKTEEIFSSEHYDTV-----KRKDSNGKVNLSYEQLP----KMHASNTSLNLPKAV 1695

Human  1242 SKP----EKVSIPERYVE--------LDPEEPPSLEELQARYRKAEKIRNILARSSMCNLQPTSG 1294
            ..|    .::|:|:.:.:        |.|..||          :....|.:...:..|.|..||.
  Fly  1696 PSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPP----------QQHHARTLSDSNYSCQLTDTSS 1750

Human  1295 QDQNSVADLDL---QLQEQERIINISYALASE-ASQRSKQVAAQQLALLPPKGPLSSRTV 1350
            :   :.:||||   :.|:|....|.|..|:|| .|...:|.:..:|.....:.|||..::
  Fly  1751 R---TSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPLSQESI 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827	2/11 (18%)
		PH_PEPP1_2_3	159..281	CDD:270068	56/121 (46%)
		NESP55	<299..460	CDD:115071	39/181 (22%)
		DUF1640	779..905	CDD:311647	29/138 (21%)
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	56/121 (46%)
		PH	372..469	CDD:278594	53/115 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003396
OrthoInspector	1	1.000	-	-		otm41640
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.100