DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PLEKHA7 and SPAC12B10.01c

DIOPT Version :9

Sequence 1:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens
Sequence 2:	NP_594633.2	Gene:	SPAC12B10.01c / 2541575	PomBaseID:	SPAC12B10.01c	Length:	1647	Species:	Schizosaccharomyces pombe

Alignment Length:	683	Identity:	124/683 - (18%)
Similarity:	219/683 - (32%)	Gaps:	243/683 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   576 PGPPRVFPPRRP------------------HTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVK 622
            || .|:.||.|.                  |:   |::|:....||...:....|.|.:...:.:
pombe   986 PG-SRIRPPFRSLVVSINGLATIRTLDNYLHS---RISVRNETGRRFSILREAGSLRESMSGSSR 1046

Human   623 NSS--HVDRRSMPSMGYMTHTV----SAPSLHGKSLEELSLLLTRLRRHQAKLASVRNFAISQLL 681
            |||  :.|..|..:..:.|...    |:.|.|.:.....||:..::         .||..|.::|
pombe  1047 NSSGDYTDSMSQDAPNHTTEPSERRDSSTSSHFEEHFVFSLMGKKV---------PRNKTIFRIL 1102

Human   682 QHQLTF--------------------PTCQADDTYLQLKKDLEY------LDLKIKNNEPLINVL 720
            ...:..                    |.|..:|    :|.:|.|      ..:.|:....|:::|
pombe  1103 YEYIQLSDDHTLDDFWKTPVPIFYGEPDCIHND----MKGELNYENETEGFSINIREILDLLSIL 1163

Human   721 YKVLKKSARGCRPRRSMTG--RDLLKDRSLKPVKIAESDTDVKLSIFCEQDRV------------ 771
            |..: :......|.:...|  .::|.|       .:......||:...|:.::
pombe  1164 YYGI-RDVHTLFPDKHFRGNIENILTD-------FSNWKLSAKLNRQLEEQQLVVHGCLPSWCIS 1220

Human   772 -------LQDLEDKIRALKENKDQL-ESVLEVLHRQMEQYRDQPQ--------HLEKIAYQQKLL 820
                   |...|.:...|:.....| .||..:|.|..|..:::..        |.:||...:|.:
pombe  1221 LTSAYPFLVPFETRYLLLQSTAFGLSRSVSFLLSRNPELSKNESSSILQFVSLHRQKIRISRKKI 1285

Human   821 QEDLVHIRAELSRESTEMENAWNEYLKLENDV-EQLKQTLQEQHRRAFFF----QEKSQIQKDLW 880
            ....:|:.|..:.....:|      ::.|::| ..|..||:       |:    :|.:....|:|
pombe  1286 FNYALHLLATYAASENILE------IEYEDEVGSGLGPTLE-------FYTSVSKEFTLNSLDIW 1337

Human   881 RIEDVTAGLSANKENFRILVESVKNPERKTV----PLFPHPPVPSLSTSESKPPPQPSPPTSPVR 941
            |.:                     .|..|.|    .||| .|:|.|.:|     |:
pombe  1338 RND---------------------QPNSKFVYQASGLFP-SPIPLLGSS-----PE--------- 1366

Human   942 TPLEVRLFPQLQTYVP------------------YRPHPPQLRKVTS----------------PL 972
            ...::.||..|..:|.                  .|..|..:..|..                |.
pombe  1367 NERKISLFFALGQFVARSIYDSRIISIQFNPLFFARNIPLTISSVAKVDKGLANSLRYLEKLIPG 1431

Human   973 QSPTKAKPKVQEDEAPPRPPLPELYSPEDQP--PAVPPLPREAT--------------IIRHTSV 1021
            ::||.|:..::         |.:|:.....|  |::..:|..|:              :|.:|..
pombe  1432 KNPTNAETDIK---------LEDLHLDFTLPGFPSIELIPDGASTPVTTFNVSDYLNYVIDYTVG 1487

Human  1022 RGLKRQSDERKRDRELGQCVNGDSRV---ELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLP 1083
            :|:::|         |....||.|.|   .....::|.||.||        .|.|..:..|.||.
pombe  1488 KGVQQQ---------LEAFQNGFSSVFPYTSLQVLTEHELVTL--------FGTVDEDWSYATLM 1535

Human  1084 GRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSK 1116
             :.:........:|.||...:||...:|.:..:
pombe  1536 -KSIVADHGYTMESPTIQRLLTLMSQMNFQEQR 1567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068
		NESP55	<299..460	CDD:115071
		DUF1640	779..905	CDD:311647	24/139 (17%)
SPAC12B10.01c	NP_594633.2	HECTc	1276..1645	CDD:238033	69/368 (19%)
SPAC12B10.01c	NP_594633.2	HECTc	1301..1642	CDD:214523	64/343 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900