Protein Alignment Gabrd and Rdl

DIOPT Version :9

• Sequence 1: XP_006538609.2
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Sequence 2: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 166/553 - (30%)
• Similarity: 244/553 - (44%)
• Gaps: 146/553 - (26%)

Mouse    63 GDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQ 127
            |..:| ::.||.:  ||.....|.:..||..||.||.|.:.:.|.||..:||..|::|:..:..|
  Fly    51 GSMLG-DVNISAI--LDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQ 112

Mouse   128 SWRDSRLSYNHTN--ETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSI 190
            .|.|.||:|....  |||.:.|.|:..:|:||||.||.|.::||..|..|:.||:...|.|..||
  Fly   113 FWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSI 177

Mouse   191 RITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRF 255
            |:|.|.:|.|:|..:|:|.|.|.:::||:||:..||.|:|.:....:.....::|.||.:..:|.
  Fly   178 RLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQ 242

Mouse   256 TTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITT 320
            ....:|. :.|.:.||:...|..|:.|.|:||.|:||.|:|.:||||||:::.|.||||:||:||
  Fly   243 RATEINL-TTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTT 306

Mouse   321 VLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPR 385
            ||||||||.|..::||:.|.:|::|||...|:|.|||:|:|||...:.|...:.||.:....:..
  Fly   307 VLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKI 371

Mouse   386 AEMDVRNAIVLFSLSAAGVSQELAISRRQGRV--PGNL---------------------MG---- 423
            ||...:        ...|.:|:.|.......|  ||.:                     ||
  Fly   372 AEQKKQ--------QLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHG 428

Mouse   424 --------------------SYRSV----------------------EVEAK------------- 433
                                |.|.:                      ||..|
  Fly   429 HGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTL 493

Mouse   434 ------------------KEGGSRPGG---------------------------PGGIR-----S 448
                              .:||..|||                           ||.::     :
  Fly   494 ENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDIN 558

Mouse   449 RLKPIDADTIDIYARAVFPAAFAAVNIIYWAAY 481
            :|..|....||.|:|.|||..|...|::||..|
  Fly   559 KLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIY 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	66/184 (36%)
		Cys-loop	198..212	CDD:349787	6/13 (46%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	49/87 (56%)
		TM1 helix	286..306	CDD:349857	13/19 (68%)
		TM2 helix	315..336	CDD:349857	13/20 (65%)
		TM3 helix	346..368	CDD:349857	11/21 (52%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	65/183 (36%)
		Neur_chan_memb	274..588	CDD:397193	81/321 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810