DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gabra6 and Rdl

DIOPT Version :9

Sequence 1:	XP_036012221.1	Gene:	Gabra6 / 14399	MGIID:	95618	Length:	459	Species:	Mus musculus
Sequence 2:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	141/364 - (38%)
Similarity:	199/364 - (54%)	Gaps:	17/364 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 LLLPWLFIILWL----------ENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTE 57
            ||..||.|.:.|          ...||...........|:|.|||:....||.|:||.:||...|
  Fly    20 LLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVE 84

Mouse    58 VKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKF-KGP-AEILSLNNLMVSKIWTPDTFFRN 120
            |...:||.|...:|:|:|::|:|.:|||.|||.||.: |.| .|.||:.:..:..||.|||||.|
  Fly    85 VGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVN 149

Mouse   121 GKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKTEII 185
            .|:|..|..||.|:..|:..:|:|..::||||.|.|||.|..||||...|.::..|:.|...:|.
  Fly   150 EKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIR 214

Mouse   186 YTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTP 250
            |.|:.| |.||.:..| ..|.|:.::|....:..|...||.|..:.......|.|||::||||.|
  Fly   215 YFWRDG-LSSVGMSSE-VELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIP 277

Mouse   251 CIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVF 315
            ..:.||:|.||||:|:.:.|||...|:|||||||||..|...:|||:||..::|.::..||..||
  Fly   278 SGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVF 342

Mouse   316 SALIEFAAVNYFTNLQSQKAERQAQTAATPPVAKSKASE 354
            ::|:|:|.|.|.......:.:|   ..|...:|:.|..:
  Fly   343 ASLLEYATVGYMAKRIQMRKQR---FMAIQKIAEQKKQQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabra6	XP_036012221.1	LGIC_ECD_GABAAR_A6	42..239	CDD:349840	78/198 (39%)
		LGIC_TM_GABAAR_alpha	242..337	CDD:349854	43/94 (46%)
		TM1 helix	245..265	CDD:349854	12/19 (63%)
		TM2 helix	274..295	CDD:349854	11/20 (55%)
		TM3 helix	305..327	CDD:349854	8/21 (38%)
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	71/184 (39%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	44/108 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910