DRSC/TRiP Functional Genomics Resources

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Protein Alignment POGLUT3 and rumi

DIOPT Version :10

Sequence 1:NP_714916.3 Gene:POGLUT3 / 143888 HGNCID:28496 Length:507 Species:Homo sapiens
Sequence 2:NP_651095.1 Gene:rumi / 326122 FlyBaseID:FBgn0086253 Length:411 Species:Drosophila melanogaster


Alignment Length:361 Identity:96/361 - (26%)
Similarity:162/361 - (44%) Gaps:44/361 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   139 EYCECPEDPQAWQKTLSCPTKEPQIAKDFASFPSINLQQMLKEVPKRFGDERGAIVHYTILNNHV 203
            :|..|..|||    ...|......:.:|.|.:.|..:.:.:.|...|:|.:      |.|..:.:
  Fly    60 DYKPCSSDPQ----DSDCSCHANVLKRDLAPYKSTGVTRQMIESSARYGTK------YKIYGHRL 114

Human   204 YRRSLGKYTDFKMFSDEILLSLTRKVLLPDLEFYVNLGDWPLEHRKVN---GTPSPIPIISWCGS 265
            ||.:...:.......:..||.|.  ..|||::..:|..|:|    ::|   |..:..|:.|:..:
  Fly   115 YRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINTRDYP----QLNAAWGNAAGGPVFSFSKT 173

Human   266 LDSRDVVLPTYDI--------THSMLEAMRGV-----TNDLLSIQGNTGPSWINKTERAFFRGRD 317
            .:.||::.|.:..        .|.     ||:     ..:.|..:....| |..|....||||..
  Fly   174 KEYRDIMYPAWTFWAGGPATKLHP-----RGIGRWDQMREKLEKRAAAIP-WSQKRSLGFFRGSR 232

Human   318 SREERLQLVQLSKENPQLLDAGITGYFFFQEKEKELG--KAKLMGFFDFFKYKYQVNVDGTVAAY 380
            :.:||..|:.||:.||:|::|..|....::..:..|.  .|..:.|.|..||||..|..|..|::
  Fly   233 TSDERDSLILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFRGVAASF 297

Human   381 RYPYLMLGDSLVLKQDSPYYEHFYMALEPWKHYVPIKR--NLSDLLEKVKWAKENDEEAKKIAKE 443
            |..:|.|..|||......:.|.||..|:||.||||:|.  :..:....:.:.|:||..|::||:.
  Fly   298 RLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEHILSFFKKNDALAQEIAQR 362

Human   444 GQLMARDLLQPHRLYCYYYQVLQKYAE--RQSSKPE 477
            |.....:.|:...:.||:.::|::|.:  :...|||
  Fly   363 GYDFIWEHLRMKDIKCYWRKLLKRYVKLLQYEVKPE 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POGLUT3NP_714916.3 Filamin 24..134
Filamin 27..131 CDD:395505
Glyco_transf_90 151..485 CDD:329112 91/349 (26%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 504..507
rumiNP_651095.1 CAP10 139..394 CDD:214773 74/264 (28%)
Blue background indicates that the domain is not in the aligned region.

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