Sequence 1: | NP_032084.2 | Gene: | Fzd8 / 14370 | MGIID: | 108460 | Length: | 685 | Species: | Mus musculus |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
Alignment Length: | 594 | Identity: | 134/594 - (22%) |
---|---|---|---|
Similarity: | 216/594 - (36%) | Gaps: | 176/594 - (29%) |
- Green bases have known domain annotations that are detailed below.
Mouse 61 TQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSMYTPIC----------LEDYKK---PLPPCRSVC 111
Mouse 112 ERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQ 176
Mouse 177 PPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMV--SVS 239
Mouse 240 SERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERF- 303
Mouse 304 KYPERPIIFLSACYLFVSVGYLVRLVAG-HEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASS 367
Mouse 368 PGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAI 432
Mouse 433 AGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMF 497
Mouse 498 LLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRW--- 559
Mouse 560 -------------EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV-VGITSGVWVWSGKTLES 610
Mouse 611 WRALCTRCC 619 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Fzd8 | NP_032084.2 | CRD_FZ8 | 31..155 | CDD:143570 | 19/107 (18%) |
Palmitate-binding groove | 71..78 | 1/6 (17%) | |||
Wnt-binding | 95..100 | 2/14 (14%) | |||
Wnt-binding | 147..152 | 0/4 (0%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 155..223 | 7/67 (10%) | |||
7tmF_FZD8 | 264..616 | CDD:320378 | 97/370 (26%) | ||
TM helix 1 | 273..298 | CDD:320378 | 8/24 (33%) | ||
TM helix 2 | 307..328 | CDD:320378 | 5/20 (25%) | ||
TM helix 3 | 395..417 | CDD:320378 | 10/21 (48%) | ||
TM helix 4 | 438..454 | CDD:320378 | 9/15 (60%) | ||
TM helix 5 | 476..499 | CDD:320378 | 7/22 (32%) | ||
TM helix 6 | 529..554 | CDD:320378 | 8/24 (33%) | ||
TM helix 7 | 577..602 | CDD:320378 | 8/25 (32%) | ||
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 606..611 | 1/4 (25%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 631..656 | ||||
PDZ-binding | 683..685 | ||||
smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 29/186 (16%) |
Frizzled | 246..568 | CDD:279827 | 96/369 (26%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |