DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fzd7 and Corin

DIOPT Version :9

Sequence 1:	NP_032083.3	Gene:	Fzd7 / 14369	MGIID:	108570	Length:	572	Species:	Mus musculus
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	161	Identity:	50/161 - (31%)
Similarity:	71/161 - (44%)	Gaps:	17/161 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    19 VLALLGALPTDTRAQP------------YHGEKGISV---PDHGFCQPISIPLC--TDIAYNQTI 66
            :||:.|.|.....|.|            .|.|...|.   |..|.|.||.:..|  ..|.||.|:
  Fly   734 LLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTV 798

Mouse    67 LPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGC 131
            .||.:||..|.:...::..:..||.|:|...:..|||:::.|.|......:|||::||....:.|
  Fly   799 FPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRC 863

Mouse   132 EALMNKFGFQWPERLRCENFPVHGAGEICVG 162
            ....:.||...||.|.|:.|....:.|.|||
  Fly   864 GFFFDVFGLSLPEYLNCKLFKDFPSSEDCVG 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fzd7	NP_032083.3	CRD_FZ7	45..169	CDD:143575	40/120 (33%)
		7tmF_FZD7	241..571	CDD:320374
		TM helix 1	250..275	CDD:320374
		TM helix 2	284..305	CDD:320374
		TM helix 3	335..361	CDD:320374
		TM helix 4	378..394	CDD:320374
		TM helix 5	416..445	CDD:320374
		TM helix 6	465..492	CDD:320374
		TM helix 7	521..546	CDD:320374
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	550..555
		PDZ-binding	570..572
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	37/115 (32%)
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900