DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fzd6 and smo

DIOPT Version :9

Sequence 1:	NP_001155966.1	Gene:	Fzd6 / 14368	MGIID:	108474	Length:	709	Species:	Mus musculus
Sequence 2:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster

Alignment Length:	679	Identity:	157/679 - (23%)
Similarity:	260/679 - (38%)	Gaps:	153/679 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    68 ECSPNIEMFLCQAFIPTCTEQIH----VVLPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPH 128
            :|...|:.|||..|.|.| |:|:    |.||..::|...:..|:.|.:|  ..:|:.|.||
  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195

Mouse   129 CDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQCAPP--------- 184
                         |...|.|            |     |:|.:|.:|.|..||..|
  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230

Mouse   185 -----------CPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295

Mouse   238 SVCYSIVSLMYFVGFLLGN--STACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWW 300
            ::|:.|..:.:.:.|..|:  ...|.| |..|...:..  ..:|.:|.|:|:.:|:|..||.||:
  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRK-DGTLRHSEPT--AGENLSCIVIFVLVYYFLTAGMVWF 357

Mouse   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVG 360
            |.||..|      .|..     :.|::|..:||.|||..|..||:..:|.::|:|::|.|:||||
  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416

Mouse   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480

Mouse   423 LYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQY---RIPCPYQANPKA----RPELALFMIKY 480
            |.||.::..:.|:|.|..:...|..::     .|:   :|...::.....    ||.:.:..:..
  Fly   481 LTLVFILVAIACHVTEFRHADEWAQSF-----RQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540

Mouse   481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605

Mouse   538 KHKKKHGAPG-------------------------PHRLKVISKSMGTSTGATTNHGTSAMAIAD 577
            .....|..|.                         |..:|......|.:||.:::||..
  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPR------ 664

Mouse   578 HDYLGQETSTEV-HTSPEA---------SVKEGRADRANTPSAKDRDCGESAGPSSKLSGNRNGR 632
            .:.|..|.|..| |.|.|:         |||  .|:.....:::.|  |:..|.||      |.|
  Fly   665 KNSLDSEISVSVRHVSVESRRNSVDSQVSVK--IAEMKTKVASRSR--GKHGGSSS------NRR 719

Mouse   633 ESRAGGLKERSNGSEGAPSEGRVSPKSSV 661
            ..|.......:.|......|...|.:|.|
  Fly   720 TQRRRDYIAAATGKSSRRRESSTSVESQV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fzd6	NP_001155966.1	CRD_FZ6	20..146	CDD:143559	22/81 (27%)
		7tmF_FZD6	188..508	CDD:320160	86/337 (26%)
		TM helix 1	198..222	CDD:320160	8/23 (35%)
		TM helix 2	231..252	CDD:320160	3/20 (15%)
		TM helix 3	283..305	CDD:320160	10/21 (48%)
		TM helix 4	326..342	CDD:320160	8/15 (53%)
		TM helix 5	364..387	CDD:320160	5/22 (23%)
		TM helix 6	418..440	CDD:320160	8/21 (38%)
		TM helix 7	469..494	CDD:320160	5/28 (18%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..709		23/89 (26%)
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	32/119 (27%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	86/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810