Protein Alignment Fzd5 and fz2

DIOPT Version :10

• Sequence 1: NP_073558.2
• Gene: Fzd5 / 14367
• MGIID: 108571
• Length: 585
• Species: Mus musculus
• Sequence 2: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 677
• Identity: 343/677 - (50%)
• Similarity: 404/677 - (59%)
• Gaps: 135/677 - (19%)

Mouse    22 GRAAAASKAP-------------VCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPL 73
            |....||.||             .|:|||:|||||||||:|..||:.||:|||||||||||||||
  Fly    40 GHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPL 104

Mouse    74 VEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138
            |||.|||||:||||||||||||.|||||||.||||||||::||:|:|:||.|.|||||:|:.||
  Fly   105 VEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLP- 168

Mouse   139 LGGDAEVLCMDY-----------------------------------------NRSEATTASPKS 162
            |.||.:.|||:.                                         ..|.:|:..|..
  Fly   169 LHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR 233

Mouse   163 FPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFV--------------PILKESHPLYNKV--- 210
            .........|.|..:||.||.      |:||.|.:              |::...|..|..:
  Fly   234 GRNSKNCQNPQGEKASGKECS------CSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQ 292

Mouse   211 RTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLS 275
            |...||||.:||..|.||.||:.||..||.|||.|||.||..|:.||:||.|||:||||||:|||
  Fly   293 RIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLS 357

Mouse   276 ACYLCVSLGFLVRLVVGHASVACS----REHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVIL 336
            |||..|::|:|.|..:.:..:||.    ||.|      |||..||:||||.||||||||||||||
  Fly   358 ACYFMVAVGYLSRNFLQNEEIACDGLLLRESS------TGPHSCTLVFLLTYFFGMASSIWWVIL 416

Mouse   337 SLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLR 401
            |.|||||||:|||||||..::|||||||||||:|:|:..|.||:|||||:.|||||||.|.:.|:
  Fly   417 SFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLK 481

Mouse   402 GFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPA 461
            .|||.||.:||::||.||:|||||||||||||||     .|.|.|||||||||||||::||||||
  Fly   482 TFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPA 546

Mouse   462 SIVVACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKT 526
            :||:.|||||..|.|.|..||  |||......|..||.|.||||||||.|.||||||||||||||
  Fly   547 TIVIGCYLYEAAYFEDWIKAL--ACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKT 609

Mouse   527 LESWRRFTSRCC-CSSRRG-------------H------------KSGGAMAAGDYAEASAALTG 565
            |||||||..|.. ...|.|             |            .:.|::.|..|.:|..|...
  Fly   610 LESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVA 674

Mouse   566 RTGPPGPTAAYH-------KQVSLSHV 585
            .|       ::|       ||.:.|||
  Fly   675 ST-------SHHHLHHHVLKQPAASHV 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fzd5	NP_073558.2	CRD_FZ5	29..156	CDD:143569	92/180 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..182		6/25 (24%)
		7tm_GPCRs	225..535	CDD:475119	210/318 (66%)
		TM helix 1	235..259	CDD:320377	14/23 (61%)
		TM helix 2	268..289	CDD:320377	13/20 (65%)
		TM helix 3	316..338	CDD:320377	19/21 (90%)
		TM helix 4	359..375	CDD:320377	12/15 (80%)
		TM helix 5	397..420	CDD:320377	11/22 (50%)
		TM helix 6	451..473	CDD:320377	16/21 (76%)
		TM helix 7	496..521	CDD:320377	19/24 (79%)
		PDZ-binding. /evidence=ECO:0000250	582..584		0/1 (0%)
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	89/119 (75%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	210/318 (66%)
		TM helix 1	316..341	CDD:320163	15/24 (63%)
		TM helix 2	350..371	CDD:320163	13/20 (65%)
		TM helix 3	396..422	CDD:320163	22/25 (88%)
		TM helix 4	439..455	CDD:320163	12/15 (80%)
		TM helix 5	477..506	CDD:320163	16/28 (57%)
		TM helix 6	531..558	CDD:320163	21/26 (81%)
		TM helix 7	579..604	CDD:320163	19/24 (79%)