DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fzd5 and fz2

DIOPT Version :9

Sequence 1:NP_001036124.1 Gene:Fzd5 / 14367 MGIID:108571 Length:585 Species:Mus musculus
Sequence 2:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster


Alignment Length:677 Identity:343/677 - (50%)
Similarity:404/677 - (59%) Gaps:135/677 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse    22 GRAAAASKAP-------------VCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPL 73
            |....||.||             .|:|||:|||||||||:|..||:.||:|||||||||||||||
  Fly    40 GHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPL 104

Mouse    74 VEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPV 138
            |||.|||||:||||||||||||.|||||||.||||||||::||:|:|:||.|.|||||:|:.|| 
  Fly   105 VEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLP- 168

Mouse   139 LGGDAEVLCMDY-----------------------------------------NRSEATTASPKS 162
            |.||.:.|||:.                                         ..|.:|:..|..
  Fly   169 LHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR 233

Mouse   163 FPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFV--------------PILKESHPLYNKV--- 210
            .........|.|..:||.||.      |:||.|.:              |::...|..|..:   
  Fly   234 GRNSKNCQNPQGEKASGKECS------CSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQ 292

Mouse   211 RTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLS 275
            |...||||.:||..|.||.||:.||..||.|||.|||.||..|:.||:||.|||:||||||:|||
  Fly   293 RIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLS 357

Mouse   276 ACYLCVSLGFLVRLVVGHASVACS----REHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVIL 336
            |||..|::|:|.|..:.:..:||.    ||.|      |||..||:||||.||||||||||||||
  Fly   358 ACYFMVAVGYLSRNFLQNEEIACDGLLLRESS------TGPHSCTLVFLLTYFFGMASSIWWVIL 416

Mouse   337 SLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLR 401
            |.|||||||:|||||||..::|||||||||||:|:|:..|.||:|||||:.|||||||.|.:.|:
  Fly   417 SFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLK 481

Mouse   402 GFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPA 461
            .|||.||.:||::||.||:|||||||||||||||     .|.|.|||||||||||||::||||||
  Fly   482 TFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPA 546

Mouse   462 SIVVACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKT 526
            :||:.|||||..|.|.|..||  |||......|..||.|.||||||||.|.||||||||||||||
  Fly   547 TIVIGCYLYEAAYFEDWIKAL--ACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKT 609

Mouse   527 LESWRRFTSRCC-CSSRRG-------------H------------KSGGAMAAGDYAEASAALTG 565
            |||||||..|.. ...|.|             |            .:.|::.|..|.:|..|...
  Fly   610 LESWRRFWRRLLGAPDRTGANQALIKQRPPIPHPYAGSGMGMPVGSAAGSLLATPYTQAGGASVA 674

Mouse   566 RTGPPGPTAAYH-------KQVSLSHV 585
            .|       ::|       ||.:.|||
  Fly   675 ST-------SHHHLHHHVLKQPAASHV 694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fzd5NP_001036124.1 CRD_FZ5 29..156 CDD:143569 92/180 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..182 6/25 (24%)
7tm_GPCRs 225..535 CDD:333717 210/318 (66%)
TM helix 1 235..259 CDD:320095 14/23 (61%)
TM helix 2 268..289 CDD:320095 13/20 (65%)
TM helix 3 316..338 CDD:320095 19/21 (90%)
TM helix 4 359..375 CDD:320095 12/15 (80%)
TM helix 5 397..420 CDD:320095 11/22 (50%)
TM helix 6 448..473 CDD:320095 19/24 (79%)
TM helix 7 496..521 CDD:320095 19/24 (79%)
PDZ-binding. /evidence=ECO:0000250 582..584 0/1 (0%)
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 89/119 (75%)
Frizzled 308..618 CDD:279827 209/317 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831144
Domainoid 1 1.000 416 1.000 Domainoid score I660
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2590
Inparanoid 1 1.050 637 1.000 Inparanoid score I827
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49270
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003114
OrthoInspector 1 1.000 - - otm43526
orthoMCL 1 0.900 - - OOG6_106776
Panther 1 1.100 - - LDO PTHR11309
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4396
SonicParanoid 1 1.000 - - X126
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.790

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