Protein Alignment Fzd4 and fz2

DIOPT Version :9

• Sequence 1: NP_032081.3
• Gene: Fzd4 / 14366
• MGIID: 108520
• Length: 537
• Species: Mus musculus
• Sequence 2: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 234/609 - (38%)
• Similarity: 319/609 - (52%)
• Gaps: 133/609 - (21%)

Mouse    15 GGVGLRLGLLLQFLLLLRPTLGFG-----DEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTD 74
            ||.||...          |..|:|     .:...||:.|.|.||:.:|||:|..||.:.||.|.:
  Fly    39 GGHGLDAS----------PAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDE 93

Mouse    75 AELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAW 139
            |.|::..|.||::..||..|:|||||:|.|:|.|..:.|:..|..:|...:..|.|:::::.|.|
  Fly    94 AGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEW 158

Mouse   140 PDTLNCSKFPPQNDHNHMCMEGPGDEEV------------------------------------- 167
            |:.:.|...|...|.:::|||.|...|.
  Fly   159 PERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGS 223

Mouse   168 -------------------PLPHKTPIQPGEECHSVGSNSDQYIWVKRSL--------------- 198
                               |...|.   .|:|| |....|......|..|
  Fly   224 SGSTSTKPCRGRNSKNCQNPQGEKA---SGKEC-SCSCRSPLIFLGKEQLLQQQSQMPMMHHPHH 284

Mouse   199 --------------NCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFS 249
                          ||.:.|  ....:|...|:|..:|:|:|:.|||.||..|:.||:||:.||.
  Fly   285 WYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFK 347

Mouse   250 YPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTG---CAIIFLLMYF 311
            ||||||:|||.||.:.::.|:.|..:..|.|:||      .:|::|  .:||   |.::|||.||
  Fly   348 YPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRE--SSTGPHSCTLVFLLTYF 404

Mouse   312 FGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGL 376
            ||||||||||||:.|||||||||||:|||..||.|||:|||.||.|:::.:|::..||.|.:.|:
  Fly   405 FGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGI 469

Mouse   377 CYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD-----GTKTDKLERLMVK 436
            |||||.|.|.|..||:||||.||||||.|:.||.|:||:|||.:::.     |.|.||||:||::
  Fly   470 CYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIR 534

Mouse   437 IGVFSVLYTVPATCVIACYFYE---ISNW--------ALFRYSADDSNMAVEMLKIFMSLLVGIT 490
            ||:||||||||||.||.||.||   ..:|        |..:........:|.|||.||:|.||||
  Fly   535 IGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGIT 599

Mouse   491 SGMWIWSAKTLHTWQKCSNRLVNS 514
            ||:||||.|||.:|::...||:.:
  Fly   600 SGVWIWSGKTLESWRRFWRRLLGA 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fzd4	NP_032081.3	CRD_FZ4	42..167	CDD:143557	47/124 (38%)
		Frizzled	210..509	CDD:279827	165/317 (52%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	499..504		3/4 (75%)
		PDZ-binding	535..537
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	46/118 (39%)
		Frizzled	308..618	CDD:279827	165/317 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820