DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fzd4 and fz2

DIOPT Version :10

Sequence 1:NP_032081.3 Gene:Fzd4 / 14366 MGIID:108520 Length:537 Species:Mus musculus
Sequence 2:NP_001401042.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:826 Species:Drosophila melanogaster


Alignment Length:609 Identity:234/609 - (38%)
Similarity:319/609 - (52%) Gaps:133/609 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse    15 GGVGLRLGLLLQFLLLLRPTLGFG-----DEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTD 74
            ||.||...          |..|:|     .:...||:.|.|.||:.:|||:|..||.:.||.|.:
  Fly    39 GGHGLDAS----------PAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDE 93

Mouse    75 AELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAW 139
            |.|::..|.||::..||..|:|||||:|.|:|.|..:.|:..|..:|...:..|.|:::::.|.|
  Fly    94 AGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEW 158

Mouse   140 PDTLNCSKFPPQNDHNHMCMEGPGDEEV------------------------------------- 167
            |:.:.|...|...|.:::|||.|...|.                                     
  Fly   159 PERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGS 223

Mouse   168 -------------------PLPHKTPIQPGEECHSVGSNSDQYIWVKRSL--------------- 198
                               |...|.   .|:|| |....|......|..|               
  Fly   224 SGSTSTKPCRGRNSKNCQNPQGEKA---SGKEC-SCSCRSPLIFLGKEQLLQQQSQMPMMHHPHH 284

Mouse   199 --------------NCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFS 249
                          ||.:.|  ....:|...|:|..:|:|:|:.|||.||..|:.||:||:.||.
  Fly   285 WYMNLTVQRIAGVPNCGIPC--KGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFK 347

Mouse   250 YPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTG---CAIIFLLMYF 311
            ||||||:|||.||.:.::.|:.|..:..|.|:||      .:|::|  .:||   |.::|||.||
  Fly   348 YPERPIVFLSACYFMVAVGYLSRNFLQNEEIACD------GLLLRE--SSTGPHSCTLVFLLTYF 404

Mouse   312 FGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGL 376
            ||||||||||||:.|||||||||||:|||..||.|||:|||.||.|:::.:|::..||.|.:.|:
  Fly   405 FGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGI 469

Mouse   377 CYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKD-----GTKTDKLERLMVK 436
            |||||.|.|.|..||:||||.||||||.|:.||.|:||:|||.:::.     |.|.||||:||::
  Fly   470 CYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIR 534

Mouse   437 IGVFSVLYTVPATCVIACYFYE---ISNW--------ALFRYSADDSNMAVEMLKIFMSLLVGIT 490
            ||:||||||||||.||.||.||   ..:|        |..:........:|.|||.||:|.||||
  Fly   535 IGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGIT 599

Mouse   491 SGMWIWSAKTLHTWQKCSNRLVNS 514
            ||:||||.|||.:|::...||:.:
  Fly   600 SGVWIWSGKTLESWRRFWRRLLGA 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fzd4NP_032081.3 CRD_FZ4 42..167 CDD:143557 47/124 (38%)
7tmF_FZD4 209..509 CDD:320166 165/318 (52%)
TM helix 1 218..243 CDD:320166 12/24 (50%)
TM helix 2 252..273 CDD:320166 10/20 (50%)
TM helix 3 303..329 CDD:320166 19/25 (76%)
TM helix 4 346..362 CDD:320166 9/15 (60%)
TM helix 5 384..413 CDD:320166 18/28 (64%)
TM helix 6 433..460 CDD:320166 20/29 (69%)
TM helix 7 470..495 CDD:320166 13/24 (54%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 499..504 3/4 (75%)
PDZ-binding 535..537
fz2NP_001401042.1 CRD_FZ5_like 63..182 CDD:143565 46/118 (39%)
7tmF_FZD5_FZD8-like 307..618 CDD:320163 165/318 (52%)
TM helix 1 316..341 CDD:320163 12/24 (50%)
TM helix 2 350..371 CDD:320163 10/20 (50%)
TM helix 3 396..422 CDD:320163 19/25 (76%)
TM helix 4 439..455 CDD:320163 9/15 (60%)
TM helix 5 477..506 CDD:320163 18/28 (64%)
TM helix 6 531..558 CDD:320163 20/26 (77%)
TM helix 7 579..604 CDD:320163 13/24 (54%)
Blue background indicates that the domain is not in the aligned region.

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