DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fzd3 and fz2

DIOPT Version :9

Sequence 1:	NP_067433.1	Gene:	Fzd3 / 14365	MGIID:	108476	Length:	666	Species:	Mus musculus
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	222/690 - (32%)
Similarity:	315/690 - (45%)	Gaps:	164/690 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 IGGHSL------------------FSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFH 66
            :|||.|                  ..||.||:.||:.:.||.|..||.:||..|..|.|.:..|.
  Fly    38 MGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFW 102

Mouse    67 PMVNLDCSRDFRPFLCALYAPICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMECSRF 130
            |:|.:.||.|.:.|||::|.|||:|.....|| ||.:|:||.|.|:.:|:.:...|||.|.|...
  Fly   103 PLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHL 167

Mouse   131 PDCDEPYPRLVDLNLVGDP----------TE---------------GAPVAVQRDYG-------- 162
            |             |.|||          ||               |:....:|..|
  Fly   168 P-------------LHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSG 219

Mouse   163 ------------------------------------------FWCPRELKIDPDLGYSFLH---- 181
                                                      .:..:|..:........:|
  Fly   220 AGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHH 284

Mouse   182 ------------VRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYP 234
                        |.:|..||...:|..:|..||..:|.|.|.:|..:||.|..||:||..||:||
  Fly   285 WYMNLTVQRIAGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYP 349

Mouse   235 ERPIIFYAVCYMMVSLIFFI-GFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTM 298
            ||||:|.:.||.||::.:.. .||..:.:||:..  ...::||   |.|  :||::|::.|||.|
  Fly   350 ERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGL--LLRESST---GPH--SCTLVFLLTYFFGM 407

Mouse   299 AGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFV 363
            |.|:|||||:.||||||..|||:|||.|.:..||.:||.||...::.:|.::.::||.|.|:|:|
  Fly   408 ASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYV 472

Mouse   364 GLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLE-----KENQDKLVKFMIRIGV 423
            |..:.|.|:.||||||.:|:|:|.:.|:||.:||.|:|..|..:     ....|||.|.|||||:
  Fly   473 GNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGI 537

Mouse   424 FSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMAL 488
            ||:||.||..:|||||.||.||...|        .:....||........:|...:.::||.|||
  Fly   538 FSVLYTVPATIVIGCYLYEAAYFEDW--------IKALACPCAQVKGPGKKPLYSVLMLKYFMAL 594

Mouse   489 IVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFA---QSLLRDPNTPIIRKSRG 550
            .|||.|..|:.|.||...|..|:            |::|..||..   |:|::. ..||.....|
  Fly   595 AVGITSGVWIWSGKTLESWRRFW------------RRLLGAPDRTGANQALIKQ-RPPIPHPYAG 646

Mouse   551 TSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLH 590
            :   |......|...:::....::||.. |..|:.|..||
  Fly   647 S---GMGMPVGSAAGSLLATPYTQAGGA-SVASTSHHHLH 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	51/154 (33%)
		Frizzled	193..512	CDD:279827	139/324 (43%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		12/53 (23%)
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	50/131 (38%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827	139/336 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810